Neutralizing antibodies against certain recently isolated viruses in the sera of human beings residing in East Africa.
Neutralizing antibodies against certain recently isolated viruses in the sera of human beings residing in East Africa.
复制标题
中和居住在东非的人类血清中最近分离出的某些病毒的抗体。
DOI：
--
复制
发表时间：
1952
影响因子：
4.4
通讯作者：
K. C. Smithburn
中科院分区：
文献类型：
--
作者：
K. C. Smithburn
最近在乌干达对 297 名乌干达和坦噶尼喀土著居民的血清进行了小鼠保护试验，使用了最近在乌干达分离出的 8 种病毒。一百三十八份血清未能中和任何病毒； 91 消灭了 8 个中的一个或另一个，但不超过 1 个； 68 份血清中和了 8 种药剂中的 1 种以上。
只有 1% 的血清中和了 Mengo 病毒，据信这种物质在采样地区可能在医学上不是很重要。来自远离每种病毒的地点和地区的血清中存在针对所有其他病毒的中和抗体。在所覆盖地区，这些病原体在人类中感染流行的大致顺序如下：布万巴热、恩塔亚、寨卡、乌干达南、西尼罗河、布尼亚姆维拉和塞姆利基森林。在这 297 名捐赠者中，对前四种指定病原体的体液免疫发生率足以表明它们相当频繁地攻击人类。
对中和一种以上病毒的血清的数据分析表明，布万巴热病毒的感染与任何其他病毒的感染无关，但恩塔亚病毒、寨卡病毒、乌干达 S 病毒或西尼罗河病毒的感染，由于这样或那样的原因，可能与该组中其他一种病毒的感染有关。 Bunyamwera 病毒和 Semliki 森林病毒可能存在类似的相关性，但针对这些病原体的血清数量太少，无法确定这一点。
Mouse protection tests with 8 viruses isolated recently in Uganda were done on the sera of 297 indigenous residents of Uganda and Tanganyika. One hundred thirty-eight sera failed to neutralize any of the viruses; 91 neutralized one or other of the 8 but no more than 1; 68 sera neutralized more than 1 of the 8 agents.
Only 1% of the sera neutralized Mengo virus, and it is believed that this agent is probably not very important medically in the localities sampled. Neutralizing antibody against all the other viruses was present in sera from various localities and areas remote from the point where each was encountered. The approximate order of prevalence of infection in human beings with these agents in the areas covered is as follows: Bwamba fever, Ntaya, Zika, Uganda S, West Nile, Bunyamwera and Semliki Forest. The incidence of humoral immunity to the first four named agents among these 297 donors is sufficient to indicate that they attack man quite frequently.
Analysis of data pertaining to sera which neutralized more than one virus indicates that infection with Bwamba fever virus occurs without relation to infection with any of the others, but that infection with Ntaya, Zika, Uganda S or West Nile virus is, for one reason or another, likely to be associated with infection by one of more others of this group. It is possible that similar correlations may exist for Bunyamwera and Semliki Forest viruses, but the number of sera protective against these agents was too small to establish this with certainty.