Antimicrobial susceptibility patterns of common and unusual species of enterococci causing infections in the United States. Enterococcal Study Group
Antimicrobial susceptibility patterns of common and unusual species of enterococci causing infections in the United States. Enterococcal Study Group
复制标题
在美国引起感染的常见和不常见肠球菌种类的抗菌药物敏感性模式。
DOI：
--
复制
发表时间：
1992
影响因子：
9.4
通讯作者：
F. Tenover
中科院分区：
文献类型：
--
作者：
S. Gordon;J. Swenson;B. Hill;N. Pigott;R. Facklam;R. Cooksey;C. Thornsberry;W. Jarvis;F. Tenover
我们收集了705株肠球菌（每例患者1株），来自美国6个地理区域的8家三级医院患者的各种解剖部位的培养物。粪肠球菌632株（90%），大肠埃希菌58株（8%）。faecium，5 E. gallinarum，4 E. avium，3 E. casseliflavus，1 E. raffinosus和1株E.分离株和1株生化变异株。粪球菌;这些分离株中的606株（86%）与临床感染有关。最常见的隔离部位为尿路（402例[57%]）、非手术伤口（94例[13%]）、血流（74例[10%]）和手术伤口（62例[9%]）。在265株（38%）分离株中检测到对庆大霉素或链霉素或两者的高水平耐药性。我们发现了两个E对万古霉素耐药的粪肠球菌分离株（MIC，32和128 μ g/ml）和产11种β-内酰胺酶的E.粪杆菌分离株。e.屎肠球菌的抗性显著高于E.粪肠球菌对青霉素、氨苄青霉素、哌拉西林、亚胺培南和环丙沙星的敏感性差异有统计学意义（P <0.001）。15个非E的MIC。粪肠球菌、非E.屎肠球菌对环丙沙星和青霉素的耐药性不同。肠球菌的抗菌药物敏感性模式因种而异，这些微生物虽然通常对高水平氨基糖苷类抗生素耐药，但也可获得对万古霉素的耐药性或产生β-内酰胺酶的能力。由于这些不同的抗微生物剂耐药机制，用目前的抗微生物剂成功治疗和控制肠球菌感染变得越来越困难。
We collected 705 isolates of enterococci (1 per patient) from cultures of a variety of anatomic sites from patients at eight tertiary-care hospitals in six geographic regions of the United States. A total of 632 (90%) Enterococcus faecalis, 58 (8%) E. faecium, 5 E. gallinarum, 4 E. avium, 3 E. casseliflavus, 1 E. raffinosus, and 1 E. hirae isolate and 1 biochemical variant of E. faecalis were identified; 606 (86%) of these isolates were associated with clinical infections. The most common sites of isolation were the urinary tract (402 [57%]), nonsurgical wounds (94 [13%]), the bloodstream (74 [10%]), and surgical wounds (62 [9%]). High-level resistance to gentamicin or streptomycin or both was detected in 265 (38%) of the isolates. We identified two E. faecalis isolates resistant to vancomycin (MICs, 32 and 128 micrograms/ml) and 11 beta-lactamase-producing E. faecalis isolates. E. faecium isolates were significantly more resistant than E. faecalis isolates to penicillin, ampicillin, piperacillin, imipenem, and ciprofloxacin (P less than 0.001). The MICs for the 15 non-E. faecalis, non-E. faecium enterococci indicated variable resistance to ciprofloxacin and the penicillins. Antimicrobial susceptibility patterns vary among species of enterococci, and these organisms, while commonly resistant to high-level aminoglycosides, can also acquire resistance to vancomycin or the ability to produce beta-lactamase. Because of these diverse antimicrobial resistance mechanisms, successful treatment and control of enterococcal infections with current antimicrobial agents are becoming increasingly difficult.
肠球菌引起的院内尿路感染。
影响因子：
--
作者：
MorrisonJr,AJ;Wenzel,RP
通讯作者：
Wenzel,RP