Correlation between Intrinsic Brain Activity and Thyroid-Stimulating Hormone Level in Unmedicated Bipolar II Depression
Correlation between Intrinsic Brain Activity and Thyroid-Stimulating Hormone Level in Unmedicated Bipolar II Depression
复制标题
未经药物治疗的 II 型双相抑郁症患者的内在大脑活动与促甲状腺激素水平之间的相关性
DOI：
10.1159/000497182
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发表时间：
2019
影响因子：
4.1
通讯作者：
Wang Ying
中科院分区：
文献类型：
--
作者：
Zhong Shuming;Chen Guanmao;Zhao Lianping;Jia Yanbin;Chen Feng;Qi Zhangzhang;Huang Li;Wang Ying
背景/目的尽管双相情感障碍（BD）患者的低频波动幅度（ALFF）和下丘脑-垂体-甲状腺轴激素水平异常已被报道，但异常ALFF与血清甲状腺激素水平之间的关系尚不清楚。然后进行常规频带（0.01- 0.1Hz）、慢-5频带（0.01- 0.027Hz）和慢-4频带（0.027- 0.073Hz）ALFF分析。另外，检测血清甲状腺激素水平，包括游离三碘甲状腺原氨酸（FT 3）、总三碘甲状腺原氨酸（TT 3）、游离甲状腺素（FT 4）、总甲状腺素（TT 4）和促甲状腺激素（TSH）。结果与HC相比，BD Ⅱ型抑郁症患者双侧楔前叶（PCu）/后扣带回（PCC）常规和慢4频段ALFF降低，右侧PCu ALFF降低，右侧枕中回（MOG）慢5频段ALFF升高。此外，与BD II抑郁症患者表现出较低的TSH水平比HC，和TSH水平呈正相关，ALFF值在双侧PCu/PCC在常规frequencyband.ConclusionsThese研究结果表明，BD II抑郁症患者显示内在的活动异常，主要是在PCu/PCC和MOG，这是与特定的频段。此外，改变内在活动的PCu/PCC可能与TSH水平在双相II抑郁症。
Background/AimsAlthough abnormalities of amplitude of low-frequency fluctuations (ALFF) and hormone levels of hypothalamus-pituitary-thyroid axis have been reported in patients with bipolar disorder (BD), the association between abnormal ALFF and serum thyroid hormone levels remains unknown.MethodA total of 90 patients with unmedicated BD II depression and 100 healthy controls (HCs) underwent resting-state functional magnetic resonance imaging, and then routine band (0.01–0.1 Hz), slow-5 band (0.01–0.027 Hz), and slow-4 band (0.027–0.073 Hz) ALFF analysis were performed. Additionally, serum thyroid hormone levels including free tri-iodothyronine (FT3), total tri-iodothyronine (TT3), free thyroxin (FT4), total thyroxin (TT4), and thyroid-stimulating hormone (TSH) were detected. The correlation between abnormal serum thyroid hormone levels and ALFF values in patients with BD II depression was calculated.ResultsCompared with the HCs, patients with BD II depression showed decreased ALFF in bilateral precuneus (PCu)/posterior cingulate cortex (PCC) in routine and slow-4 frequency bands, decreased ALFF in the right PCu, and increased ALFF in the right middle occipital gyrus (MOG) in the slow-5 frequency band. Additionally, patients with BD II depression showed lower TSH level than HCs, and TSH level was positively correlated with ALFF values in the bilateral PCu/PCC in the routine frequency band.ConclusionsThese findings suggest that patients with BD II depression display intrinsic activity abnormalities, mainly in the PCu/PCC and MOG, which are associated with specific frequency bands. Moreover, altered intrinsic activity in the PCu/PCC may be related to TSH levels in bipolar II depression.