The importance of strain variation in virulence of Candida dubliniensis and Candida albicans: results of a blinded histopathological study of invasive candidiasis
The importance of strain variation in virulence of Candida dubliniensis and Candida albicans: results of a blinded histopathological study of invasive candidiasis
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DOI：
10.1111/j.1469-0691.2009.02840.x
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发表时间：
2009-06-01
影响因子：
14.2
通讯作者：
Gottfredsson, M.
中科院分区：
文献类型：
--
作者：
Asmundsdottir, L. R.;Erlendsdottir, H.;Gottfredsson, M.
越来越多的报道称，致病性酵母念珠菌是全身性真菌感染的原因。我们在侵袭性念珠菌病鼠模型中比较了 9 种都柏林念珠菌临床血流分离株与 3 种白色念珠菌分离株的毒力。以盲法、系统的方式评估受感染动物肾脏中生物体的定量和炎症变化。感染都柏林隐球菌的动物平均 7 天死亡率为 21.0%（33/157 只动物；菌株范围：0-57.1%）；白色念珠菌为 23.2%（23/99 只动物；菌株范围：6.7-85.0%）（p < 0.65）。物种内的应变变异比两个物种之间的变异更大。这两个物种都包含高毒力或低毒力的菌株，九个都柏林念珠菌菌株中有六个显示出可忽略不计的毒力。对肝脏和肾脏样本测定的菌落计数在物种之间没有差异。根据组织病理学分析，都柏林念珠菌产生的菌丝水平显着低于白色念珠菌 (p
The pathogenic yeast Candida dubliniensis is increasingly reported as a cause of systemic fungal infections. We compared the virulence of 9 clinical bloodstream isolates of C. dubliniensis with 3 C. albicans isolates in a murine model of invasive candidiasis. Quantification of organisms and inflammatory changes in kidneys of infected animals were evaluated in a blinded, systematic manner. Average 7-day mortality among animals infected with C. dubliniensis was 21.0% (33/157 animals; range for strains: 0-57.1%); and with C. albicans 23.2%, (23/99 animals; range for strains: 6.7-85.0%) (p 0.65). Greater strain variation was noted within species than between the two species. Both species comprised strains of either high or low virulence, and six of the nine C. dubliniensis strains showed negligible virulence. Colony counts determined on samples from liver and kidneys did not differ between species. According to histopathological analysis, C. dubliniensis produced significantly lower levels of hyphae than C. albicans (p