SARS-CoV-2 Antibodies Detected in Mother's Milk Post-Vaccination
SARS-CoV-2 Antibodies Detected in Mother's Milk Post-Vaccination
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DOI：
10.1177/08903344211030168
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发表时间：
2021-07-23
影响因子：
2.6
通讯作者：
Baird, Jason R.
中科院分区：
文献类型：
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作者：
Baird, Jill K.;Jensen, Shawn M.;Baird, Jason R.
背景严重急性呼吸综合征冠状病毒2(SARS-CoV-2)大流行已在全球范围内感染了1.27亿人，其中近280万人在撰写本文时死亡。由于没有哺乳期个体被纳入疫苗安全性和有效性的初步试验，因此需要对哺乳期妇女接种SARS-CoV-2疫苗以及通过母乳向婴儿传播被动免疫的可能性进行研究，以指导患者、临床医生和政策制定者在全球范围内遏制这种病毒传播的努力中是否建议接种疫苗。研究的目的是(1)确定接种SARS-CoV-2后母乳中是否存在SARS-CoV-2特异性免疫球蛋白，以及(2)表征存在的免疫球蛋白的时间过程和类型。方法对计划在2020年12月至2021年1月期间接种辉瑞-BioNTech或莫德纳SARS-CoV-2疫苗的哺乳期妇女(N=7)进行纵向队列研究，提供乳汁样本。这些是在接种疫苗前和在另外11个时间点收集的，最后一次样本是在第二剂疫苗接种后14天。分析样本中SARS-CoV-2特异性免疫球蛋白A和G(IgA和IgG)的水平。结果在首次接种疫苗后7天左右，我们观察到母乳中SARS-CoV-2特异性免疫球蛋白抗体和免疫球蛋白A抗体水平显著升高，以免疫球蛋白为主。结论母婴免疫可在母乳中产生SARS-CoV-2特异性免疫球蛋白，可能对婴儿有保护作用。
Background The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic has infected over 127 million people worldwide, with almost 2.8 million deaths at the time of writing. Since no lactating individuals were included in initial trials of vaccine safety and efficacy, research on SARS-CoV-2 vaccination in lactating women and the potential transmission of passive immunity to the infant through mother's milk is needed to guide patients, clinicians, and policy makers on whether to recommend immunization during the worldwide effort to curb the spread of this virus. Research Aims (1) To determine whether SARS-CoV-2 specific immunoglobins are found in human milk after vaccination, and (2) to characterize the time course and types of immunoglobulins present. Methods A longitudinal cohort study of lactating women (N = 7) who planned to receive both doses of the Pfizer-BioNTech or Moderna SARS-CoV-2 vaccine between December 2020 and January 2021 provided milk samples. These were collected pre-vaccination and at 11 additional timepoints, with the last sample at 14 days after the second dose of vaccine. Samples were analyzed for levels of SARS-CoV-2 specific immunoglobulins A and G (IgA and IgG). Results We observed significantly elevated levels of SARS-CoV-2 specific IgG and IgA antibodies in human milk beginning approximately 7 days after the initial vaccine dose, with an IgG-dominant response. Conclusions Maternal vaccination results in SARS-CoV-2 specific immunoglobulins in human milk that may be protective for infants.