PRELIMINARY FINDINGS OF ALTERED FOLLICULAR ACTIVITY IN HOLSTEIN COWS WITH COAGULATION-FACTOR-XI DEFICIENCY
PRELIMINARY FINDINGS OF ALTERED FOLLICULAR ACTIVITY IN HOLSTEIN COWS WITH COAGULATION-FACTOR-XI DEFICIENCY
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DOI：
10.1007/bf01839334
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发表时间：
1995-12-01
影响因子：
2.2
通讯作者：
CUMMINGS, E
中科院分区：
文献类型：
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作者：
LIPTRAP, RM;GENTRY, PA;CUMMINGS, E
因子XI （fxi）缺乏症是一种常染色体隐性凝血病，发现于荷斯坦牛。受感染的动物重复繁殖的发生率高出50%。因此，对描述卵巢功能的几个参数进行了研究。每日血液采样显示，fxii缺乏症奶牛的孕酮浓度下降速度较慢，从第16天的峰值（p < 0.01）降至低于3 nmol/L (5.14 +/- 0.69 d（平均+/- SD），对照组为4.05 +/- 0.63 d)，发情周期为24.7 +/- 2.1 d，对照组为22.9 +/- 3.0 d。这不是由于参与黄体溶解的前列腺素F-2 α (PGF(2 α))或催产素（OT）的可用性的改变。正常奶牛（n = 7）和fxii缺乏奶牛（n = 7）在第12天至第14天之间，在响应OT刺激的13,14-二氢-15-酮PGF（2 α）脉冲的峰值或曲线下面积，以及描述PGF（2 α）注射后卵巢分泌脉搏的参数（各n = 7）方面，均无显著差异（p > 0.05）。通过超声监测排卵卵泡发育，并在每隔8小时注射氯前列醇后测定血浆17 β -雌二醇值（n = 6）。fxi缺乏症奶牛卵泡直径更小（p < 0.05），接近排卵期雌二醇峰值值更低。结果表明，fxi缺乏症奶牛的发情周期特征是黄体溶解过程较慢，这可能与卵泡发育较小有关。
Factor XI (F XI) deficiency is an autosomal recessive coagulopathy found in Holstein cattle. Affected animals have a 50% greater prevalence of repeat breeding. Therefore, several parameters describing ovarian function were studied. Daily blood sampling revealed that progesterone concentrations were slower to decline from a peak at day 16 (p < 0.01) to values less than 3 nmol/L in F XI-deficient cows (5.14 +/- 0.69 days (mean +/- SD) versus 4.05 +/- 0.63 days in control animals), resulting in an oestrous cycle length of 24.7 +/- 2.1 days compared to 22.9 +/- 3.0 days, respectively. This was not due to an alteration in the availability of prostaglandin F-2 alpha (PGF(2 alpha)) or oxytocin (OT) involved in luteolysis. No significant differences (p > 0.05) were seen between normal (n = 7) and F XI-deficient (n = 7) cows in the peak values or the area under the curve for the pulse in 13,14-dihydro-15-keto PGF(2 alpha) in response to OT challenge or in the parameters describing the pulse of ovarian OT secretion after PGF(2 alpha) injection (n = 7 for each) between days 12 and 14. Ovulatory follicular development was assessed by ultrasound monitoring and plasma 17 beta-oestradiol values at 8-h intervals after a luteolytic injection of cloprostenol (n = 6 for each). Follicular diameter was smaller (p < 0.05) and accompanied by lower peak oestradiol values near the time of ovulation in F XI-deficient cows. The results suggest that the oestrous cycle in F XI-deficient cows is characterized by a slower process of luteolysis that may be associated with smaller follicular development.