Perinatal and juvenile social environments interact to shape cognitive behaviour and neural phenotype in prairie voles.
Perinatal and juvenile social environments interact to shape cognitive behaviour and neural phenotype in prairie voles.
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围产期和青少年的社会环境相互作用，塑造草原田鼠的认知行为和神经表型。
DOI：
10.1098/rspb.2015.2236
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Ophir,AlexanderG
中科院分区：
文献类型：
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作者：
Prounis,GeorgeS;Foley,Lauren;Rehman,Asad;Ophir,AlexanderG
不同发育阶段所经历的社会环境深刻地塑造了成年人的行为和神经表型，并可能产生重要的相互作用。我们问，如果断奶前后的社会经验影响成年雄性草原田鼠的社会认知。动物要么有父亲，要么没有父亲，然后要么单独饲养，要么以兄弟姐妹成对的方式饲养。社会剥夺前（无父）和断奶后（单独圈养）的男性没有表现出社会认可或社会信息的空间分离。我们还检查了与社会行为和记忆相关的前脑区域的催产素和加压素受体（OTR和V1aR）。断奶前和断奶后的经验差异改变受体表达在几个结构。值得注意的是，在侧隔（催产素抑制社会认知的区域）的OTR在没有明显表现出社会认知的动物中最大。缺席的父亲在V1aR在压后皮质和单一住房OTR在隔海马核的组合产生了一个独特的表型，以前发现与穷人的生殖成功的性质。我们证明，在整个发展过程中的早期生活经历的互动效应对大脑行为表型有巨大的影响，可以缓冲潜在的负面结果，由于社会剥夺。
Social environments experienced at different developmental stages profoundly shape adult behavioural and neural phenotypes, and may have important interactive effects. We asked if social experience before and after weaning influenced adult social cognition in male prairie voles. Animals were raised either with or without fathers and then either housed singly or in sibling pairs. Males that were socially deprived before (fatherless) and after (singly housed) weaning did not demonstrate social recognition or dissociate spatial from social information. We also examined oxytocin and vasopressin receptors (OTR and V1aR) in areas of the forebrain associated with social behaviour and memory. Pre- and post-wean experience differentially altered receptor expression in several structures. Of note, OTR in the lateral septum—an area in which oxytocin inhibits social recognition—was greatest in animals that did not clearly demonstrate social recognition. The combination of absentee fathers on V1aR in the retrosplenial cortex and single housing on OTR in the septohippocampal nucleus produced a unique phenotype previously found to be associated with poor reproductive success in nature. We demonstrate that interactive effects of early life experiences throughout development have tremendous influence over brain–behaviour phenotype and can buffer potentially negative outcomes due to social deprivation.