CBF changes in drug naive juvenile myoclonic epilepsy patients
CBF changes in drug naive juvenile myoclonic epilepsy patients
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DOI：
10.1007/s00415-006-0491-6
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发表时间：
2007-08-01
影响因子：
6
通讯作者：
Hong, Seung Bong
中科院分区：
文献类型：
--
作者：
Tae, Woo Suk;Joo, Eun Yeon;Hong, Seung Bong
丘脑和脑干在全身性癫痫中的作用已在以往的研究中得到证实。本研究的目的是评估青少年肌阵挛性癫痫（JME）患者的区域脑血流量（rCBF）异常。采用tc -99-乙基半胱氨酸二聚体脑单光子发射计算机断层扫描（SPECT）对19例未用药的JME患者和25例年龄、性别分布相似的正常人进行扫描。采用独立t检验对脑SPECT图像进行统计参数映射，比较JME组与正常对照组rCBF的差异。JME组rCBF与癫痫发作年龄或病程之间进行SPM回归分析。与正常对照组相比，JME组双侧丘脑、红核、中脑、脑桥、左侧海马和小脑rCBF显著减少（FDR校正p < 0.01），而左侧额上回rCBF增加（未校正p < 0.001， FDR校正p < 0.05）。病程与双侧额皮质、尾状核、脑干和小脑扁桃体的rCBF呈负相关。我们的研究结果表明，丘脑、海马、脑干和小脑的异常神经网络与JME有关。
The role of thalamus and brainstem in generalized epilepsy has been suggested in previous studies. The aim of the present study was to assess regional cerebral blood flow (rCBF) abnormality in juvenile myoclonic epilepsy (JME) patients.Tc-99-ethylcysteinate dimer brain single photon emission computed tomography (SPECT) was performed in 19 drug naive JME patients and 25 normal controls with the similar age and gender distribution. Differences of rCBF between a JME group and a normal control group were examined by the statistical parametric mapping of brain SPECT images using independent t test. The regression analyses in SPM were also performed between rCBF and the age of seizure onset or the disease duration in JME group.Compared to normal controls, the JME group showed a significant rCBF reduction in bilateral thalami, red nucleus, midbrain, pons, left hippocampus, and in the cerebelli (FDR corrected p < 0.01) whereas rCBF increase in the left superior frontal gyrus (uncorrected p < 0.001 but FDR corrected p > 0.05). Disease duration was negatively correlated with rCBF in bilateral frontal cortices, caudate nuclei, brainstem and cerebellar tonsils.Our results suggest that abnormal neural networks in the thalamus, hippocampus, brainstem and cerebellum are associated with JME.