Fat malabsorption and increased intestinal oxalate absorption are common after Roux-en-Y gastric bypass surgery.
Fat malabsorption and increased intestinal oxalate absorption are common after Roux-en-Y gastric bypass surgery.
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DOI：
10.1016/j.surg.2010.11.015
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发表时间：
2011-05
期刊：
影响因子：
3.8
通讯作者：
Li, Xujian
中科院分区：
文献类型：
--
作者：
Kumar, Rajiv;Lieske, John C.;Collazo-Clavell, Maria L.;Sarr, Michael G.;Olson, Ellen R.;Vrtiska, Terri J.;Bergstralh, Eric J.;Li, Xujian
高尿酸和草酸钙结石形成增加发生在Rouxen-Y胃旁路术（RYGB）治疗病态肥胖后.这种高尿症的病因尚不清楚。我们假设减肥手术后，肠道对草酸盐的过度吸收导致血浆草酸盐和尿草酸钙过饱和度增加。我们前瞻性检测了11例病态肥胖受试者在RYGB（n = 9）和胆胰十二指肠转位术（n =2）之前和之后6个月和12个月的草酸盐代谢。我们测量了24小时尿草酸钙、磷灰石、透钙磷石、尿酸和尿酸钠的过饱和度，空腹血浆草酸盐，72小时粪便脂肪，以及口服草酸盐负荷后尿草酸盐的增加。RYGB手术后6个月和12个月，与手术前获得的类似测量值相比，血浆草酸盐和尿草酸钙过饱和度显著增加（P值均≤0.02）。6个月和12个月时的粪便脂肪排泄量增加（P值，0.026和0.055，0 vs 6个月和12个月）。在6个月和12个月时观察到口服草酸盐后尿草酸盐排泄增加（P值均≤0.02）。因此，在减肥手术后，观察到粪便脂肪排泄、口服草酸负荷后尿草酸排泄、血浆草酸和尿草酸钙过饱和值增加。肠源性高尿症常出现在RYGB和BPD-DS手术后的患者中，这些手术利用肠吸收不良作为减肥机制。
Hyperoxaluria and increased calcium oxalate stone formation occur after Rouxen- Y gastric bypass (RYGB) surgery for morbid obesity. The etiology of this hyperoxaluria is unknown. We hypothesized that after bariatric surgery, intestinal hyperabsorption of oxalate contributes to increases in plasma oxalate and urinary calcium oxalate supersaturation. We prospectively examined oxalate metabolism in 11 morbidly obese subjects prior to and 6 and 12 months after RYGB (n = 9) and biliopancreatic diversion-duodenal switch (n =2). We measured 24 hour urinary supersaturations for calcium oxalate, apatite, brushite, uric acid, and sodium urate, fasting plasma oxalate, 72 hour fecal fat, and increases in urine oxalate following an oral oxalate load. Six and 12 months after RYGB surgery, plasma oxalate and urine calcium oxalate supersaturation increased significantly compared to similar measurements obtained prior to surgery (P values all ≤0.02). Fecal fat excretion at 6 and 12 months was increased (P-value, 0.026 and 0.055, 0 vs 6 and 12 months). An increase in urine oxalate excretion after an oral dose of oxalate was observed at 6 and 12 months (P-values ≤0.02 each). Therefore, after bariatric surgery, increases in fecal fat excretion, urinary oxalate excretion after an oral oxalate load, plasma oxalate, and urinary calcium oxalate supersaturation values were observed. Enteric hyperoxaluria is often present in patients after the operations of RYGB and BPD-DS that utilize an element of intestinal malabsorption as a mechanism for weight loss.
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影响因子：
120.7
作者：
Flegal, Katherine M.;Carroll, Margaret D.;Curtin, Lester R.
通讯作者：
Curtin, Lester R.
影响因子：
1.6
作者：
Breznikar, B.;Dinevski, D.
通讯作者：
Dinevski, D.
影响因子：
6.6
作者：
Duffey, Branden G.;Pedro, Renato N.;Monga, Manoj
通讯作者：
Monga, Manoj
影响因子：
6.6
作者：
Asplin, John R.;Coe, Fredric L.
通讯作者：
Coe, Fredric L.
DOI：
10.1016/j.soard.2005.07.002
发表时间：
2005-09-01
期刊：
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
影响因子：
--
作者：
Nelson, Wayne K;Houghton, Scott G;Sarr, Michael G
通讯作者：
Sarr, Michael G