Age-related changes in periodic leg movements during sleep in patients with restless legs syndrome
Age-related changes in periodic leg movements during sleep in patients with restless legs syndrome
复制标题
DOI：
10.1016/j.sleep.2007.08.020
复制
发表时间：
2008-10-01
期刊：
影响因子：
4.8
通讯作者：
Zucconi, Marco
中科院分区：
文献类型：
--
作者：
Ferri, Raffaele;Manconi, Mauro;Zucconi, Marco
目的：本研究的目的是评估和统计描述一大批患有不宁腿综合征（RLS）的受试者在睡眠中腿部运动（LMs）的年龄相关变化。对象和方法：本研究纳入了108例未经治疗的特发性RLS患者（平均年龄52.0岁）。最小7.5岁，最大83.2岁)。使用一种特别适合于评估其数量、周期性和夜间分布的方法，对他们的多导睡眠仪记录的LMs的时间结构进行了分析。结果：各年龄组睡眠中周期性LMs （PLMS）数量逐渐增加。55岁前的典型发病间隔约为24 ~ 28 s， 65岁后的典型发病间隔约为14 ~ 16 s。PLMS指数在15-25岁时达到平台期，并在65岁时保持稳定，在此年龄段之后，PLMS指数出现了重要的上升。周期指数（PI）在35岁前逐渐增大，在85岁前保持稳定。PLMS指数与PI无相关性。在15-75岁的受试者中，每小时睡眠的PLMS数量在夜间下降；在这个年龄之后，PLMS倾向于在整个晚上均匀分布。结论：通过分析RLS患者睡眠过程中腿部运动活动的三个主要参数（PLMS指数、P1和PLMS时间分布），可以为我们提供该情况下PLMS的年龄相关变化的重要信息，可用于评价RLS患者的睡眠运动模式。(C) 2007 Elsevier B.V.版权所有
Objective: The aim of this study was to evaluate and statistically describe the age-related changes in leg movements (LMs) during sleep in a large group of subjects with restless legs syndrome (RLS).Subjects and methods: One hundred eight untreated patients affected by idiopathic RLS were included in this study (mean age 52.0 years. min 7.5, max 83.2 years). The time structure of their polysomnographically recorded LMs was analyzed using an approach particularly appropriate for assessing their quantity, periodicity, and distribution during the night.Results: Periodic LMs during sleep (PLMS) increased in number gradually in the age groups. Their typical interval was approximately 24-28 s before the age of 55 years but at approximately 14-16 s after the age of 65 years. PLMS index reached a plateau at 15-25 years of age and remained stable Lip to 65 years: after this age, it showed an important increase. Periodicity index (PI) increased progressively up to the age of 35 years and then remained stable up to the age of 85 years. No correlation was found between PLMS index and PI. The number of PLMS per hour of sleep declined through the night in Subjects aged 15-75 years; after this age, PLMS tended to be equally distributed across the entire night.Conclusions: The use of three main parameters derived from the analysis of leg motor activity during sleep in RLS patients (PLMS index, P1 and PLMS time distribution) is capable of providing us with important information about the age-related changes of PLMS in this condition, which can be used in the evaluation of the sleep motor patterns in these subjects. (C) 2007 Elsevier B.V. All rights reserved.