Muscle Weakness After Repeated Injection of Botulinum Toxin Type A Evaluated According to Bite Force Measurement of Human Masseter Muscle
Muscle Weakness After Repeated Injection of Botulinum Toxin Type A Evaluated According to Bite Force Measurement of Human Masseter Muscle
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DOI：
10.1111/j.1524-4725.2009.01319.x
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发表时间：
2009-12-01
影响因子：
2.4
通讯作者：
Kim, Seong Taek
中科院分区：
文献类型：
--
作者：
Kim, Ki Seo;Byun, Young Sub;Kim, Seong Taek
背景A型肉毒毒素(BTX-A)已被成功地应用于治疗咬肌肥大，但它可导致肌肉无力。目的测量BTX-A注射入人咬肌后最大咬合力(MBF)的变化，并评价重复注射对MBF的影响。方法志愿者完成18周的随访，测量MBF。结果注射后2周MBF较注射前下降约20%，4周后逐渐恢复至注射前水平。MBF在注药前与注药后2、4、8周比较差异有统计学意义(P
BACKGROUNDBotulinum toxin type A (BTX-A) has been applied successfully to treat masseteric hypertrophy, but it can cause muscle weakness.OBJECTIVETo measure the change in maximum bite force (MBF) after BTX-A injection into the human masseter muscle and to evaluate the influence of a booster (repeated) injection.METHODSThirty volunteers completed 18-week follow-up, and MBF was measured. At 18 weeks after the first injection, a booster injection was given to 14 patients, and they were followed up until 18 weeks from the booster injection.RESULTSMean MBF was approximately 20% lower at 2 weeks than before the injection, and it recovered gradually after 4 weeks to return to the preinjection level at 12 weeks. MBF differed significantly between before the injection and at 2, 4, and 8 weeks after the injection (p