CORNIFIED CELL-ENVELOPE
CORNIFIED CELL-ENVELOPE
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DOI：
10.1159/000248031
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发表时间：
1990-01-01
期刊：
影响因子：
--
通讯作者：
HOHL, D
中科院分区：
文献类型：
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作者：
HOHL, D
角质化细胞膜（CE）是终末分化角质形成细胞质膜内侧的高度不溶性结构。概述了 CE 的细胞和分子生物学，并回顾了涉及 CE 的新研究领域，重点是形态和生化联系、终末分化过程中的顺序基因表达、形成表皮屏障的脂质和蛋白质的相互作用、表皮中富含半胱氨酸的蛋白质库以及 CE 主要成分的分子克隆和/或表征。
The cornified cell envelope (CE) is a highly insoluble structure on the inside of the plasma membrane of terminally differentiated keratinocytes. The cellular and molecular biology of the CE is outlined and new areas of research involving the CE are reviewed focussing on morphological and biochemical connections, the sequential gene expression during terminal differentiation, the interaction of lipids and proteins forming the epidermal barrier, the cysteine-rich pool of proteins in the epidermis as well as the molecular cloning and/or characterization of major components of the CE.