Relapse to cocaine-seeking after hippocampal theta burst stimulation
Relapse to cocaine-seeking after hippocampal theta burst stimulation
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DOI：
10.1126/science.1058043
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发表时间：
2001-05-11
期刊：
影响因子：
56.9
通讯作者：
Gardner, EL
中科院分区：
文献类型：
--
作者：
Vorel, SR;Liu, XH;Gardner, EL
可卡因成瘾的治疗工作因复发率高而受到阻碍。为了绘制复发的大脑区域，我们在大鼠可卡因自我给药行为消失后使用脑电刺激和颅内注射药物化合物。电刺激含有多巴胺能纤维的海马，但不是含有多巴胺能纤维的内侧前脑束，引起依赖于腹侧被盖区谷氨酸的可卡因寻求行为。这表明可卡因滥用复发中的多巴胺能神经传递的作用。内侧前脑束电极支持强烈的电自我刺激。这些研究结果表明，分离的神经系统subserving积极的强化（自我刺激）和激励动机（复发）。
Treatment efforts for cocaine addiction are hampered by high relapse rates. To map brain areas underlying relapse, we used electrical brain stimulation and intracranial injection of pharmacological compounds after extinction of cocaine self-administration behavior in rats. Electrical stimulation of the hippocampus containing glutamatergic fibers, but not the medial forebrain bundle containing dopaminergic fibers, elicited cocaine-seeking behavior dependent on glutamate in the ventral tegmental area. This suggests a role for glutamatergic neurotransmission in relapse to cocaine abuse. The medial forebrain bundle electrodes supported intense electrical self-stimulation. These findings suggest a dissociation of neural systems subserving positive reinforcement (self-stimulation) and incentive motivation (relapse).