A SPECT Camera for Combined MRI and SPECT for Small Animals.
A SPECT Camera for Combined MRI and SPECT for Small Animals.
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用于小动物组合 MRI 和 SPECT 的 SPECT 相机。
DOI：
10.1016/j.nima.2010.09.116
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Tsui,BMW
中科院分区：
文献类型：
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作者：
Meier,D;Wagenaar,DJ;Chen,S;Xu,J;Yu,J;Tsui,BMW
我们描述了一款适用于小动物的 MR 兼容 SPECT 相机。 SPECT 相机系统可以插入最先进的 MRI 系统的孔中，使研究人员能够通过 MRI 和 SPECT 同时采集来获取小鼠体内的断层图像。 SPECT 系统提供功能信息，而 MRI 提供解剖信息。直到今天，由于相互干扰，传统的 SPECT 仍无法在 MRI 内进行操作。新的 SPECT 技术基于半导体辐射传感器（CZT、ASIC），适合孔径最小为 12 厘米的传统高场 MRI 系统。 SPECT 相机配有 MR 兼容的多针孔准直器，适用于具有 Ø25 毫米视场的小鼠。对于此处报告的工作，我们组装了原型 SPECT 相机系统，并使用 MRI 外部和内部的相机从放射源和分辨率模型获取 SPECT 和 MRI 数据。
We describe an MR-compatible SPECT camera for small animals. The SPECT camera system can be inserted into the bore of a state-of-the-art MRI system and allows researchers to acquire tomographic images from a mouse in-vivo with the MRI and the SPECT acquiring simultaneously. The SPECT system provides functional information, while MRI provides anatomical information. Until today it was impossible to operate conventional SPECT inside the MRI because of mutual interference. The new SPECT technology is based on semiconductor radiation sensors (CZT, ASICs), and it fits into conventional high field MRI systems with a minimum 12-cm bore size. The SPECT camera has an MR-compatible multi-pinhole collimator for mice with a Ø25-mm field-of-view. For the work reported here we assembled a prototype SPECT camera system and acquired SPECT and MRI data from radioactive sources and resolution phantoms using the camera outside and inside the MRI.