Extracellular matrix-driven matrix metalloproteinase production in endothelial cells: Implications for angiogenesis
Extracellular matrix-driven matrix metalloproteinase production in endothelial cells: Implications for angiogenesis
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DOI：
10.1016/s1050-1738(99)00014-6
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发表时间：
1999-04-01
影响因子：
9.3
通讯作者：
Madri, JA
中科院分区：
文献类型：
--
作者：
Haas, TL;Madri, JA
新血管生长的过程，即血管生成，涉及内皮细胞与相邻细胞以及与底层基底膜基质组分相互作用的协调改变。基质金属蛋白酶（MMP），蛋白酶，可以切割基底膜和间质基质分子，已被证明是必要的血管生成，因为它发生在几个不同的体内和体外模型。这篇综述讨论了两个特定的基质金属蛋白酶，MMP-2和MT 1-MMP，在血管生成中的潜在作用，强调目前的理解如何内皮细胞-细胞外基质的相互作用可能会调节这些基质金属蛋白酶的生产通过基质诱导的信号传导，导致转录激活和随后形成的活性多蛋白酶复合物的细胞表面。（Trends Endovasc Med 1999;9：70-77）。(C)1999年，Elsevier Science Inc.
The process of new blood vessel growth, angiogenesis, involves orchestrated alterations in endothelial cell interactions with adjacent cells and with components of the underlying basement membrane matrix. The activity of matrix metalloproteinases (MMPs), proteases that can cleave basement membrane and interstitial matrix molecules, has been shown to be necessary for angiogenesis as it occurs in several different in vivo and in vitro models. This review discusses the potential roles of two particular MMPs, MMP-2 and MT1-MMP, in angiogenesis, with emphasis on current understanding of how endothelial cell-extracellular matrix interactions may regulate the production of these MMPs via matrix-induced signaling leading to transcriptional activation and subsequent formation of active multiprotease complexes on the cell surface. (Trends Cardiovasc Med 1999;9:70-77). (C) 1999, Elsevier Science Inc.