Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment.
Inflammation and immunity in schizophrenia: implications for pathophysiology and treatment.
复制标题
DOI：
10.1016/s2215-0366(14)00122-9
复制
发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Jones PB
中科院分区：
文献类型：
--
作者：
Khandaker GM;Cousins L;Deakin J;Lennox BR;Yolken R;Jones PB
免疫系统和大脑之间复杂的相互作用可能对神经精神脑疾病具有重要的病因学和治疗意义。早在一个多世纪前，人们就推测精神分裂症和免疫系统之间可能存在关联，并得到流行病学和遗传学研究的支持，这些研究指出精神分裂症与感染和炎症有关。与传统观点相反，过去20年的研究发现，免疫系统、全身炎症和大脑之间存在复杂的相互作用，这可能导致情绪、认知和行为的变化。在这篇综述中，我们描述了一些关于精神分裂症和相关精神疾病的先天性和适应性免疫反应的重要研究领域，我们认为这些研究将引起精神病临床医生和研究人员的兴趣。我们讨论了这些发现的潜在机制和治疗意义，包括抗炎药物在精神分裂症中的研究，描述了发展领域，并为未来的研究提供了可测试的假设。
Complex interactions between the immune system and the brain might have important aetiological and therapeutic implications for neuropsychiatric brain disorders. A possible association between schizophrenia and the immune system was postulated over a century ago, and is supported by epidemiological and genetic studies pointing to links with infection and inflammation. Contrary to the traditional view that the brain is an immunologically privileged site shielded behind the blood–brain barrier, studies in the past 20 years have noted complex interactions between the immune system, systemic inflammation, and the brain, which can lead to changes in mood, cognition, and behaviour. In this Review, we describe some of the important areas of research regarding innate and adaptive immune response in schizophrenia and related psychotic disorders that, we think, will be of interest to psychiatric clinicians and researchers. We discuss potential mechanisms and therapeutic implications of these findings, including studies of anti-inflammatory drugs in schizophrenia, describe areas for development, and offer testable hypotheses for future investigations.