StimVision v2: Examples and Applications in Subthalamic Deep Brain Stimulation for Parkinson's Disease.
StimVision v2: Examples and Applications in Subthalamic Deep Brain Stimulation for Parkinson's Disease.
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DOI：
10.1111/ner.13350
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
McIntyre CC
中科院分区：
文献类型：
--
作者：
Noecker AM;Frankemolle-Gilbert AM;Howell B;Petersen MV;Beylergil SB;Shaikh AG;McIntyre CC
下丘脑深部脑刺激（DBS）是帕金森病的一种成熟的治疗方法。DBS连接组建模是一个新兴的子研究领域，旨在表征DBS激活的轴突连接。本文描述了我们发展StimVision软件平台的方法和方法，以满足丘脑底区连接组DBS建模的技术需求。StimVision v2是使用visualtoolkit （VTK）库开发的，集成了四个主要组件：1)医学图像可视化，2)轴突通路可视化，3)电极定位，4)刺激计算。StimVision v2实现了两个关键的技术进步，用于丘脑下区域的连接组DBS分析。首先是将解剖轴突通路模型应用于患者特异性DBS模型。二是应用一种新的驱动力方法来估计轴突通路对DBS的反应。给出了定向DBS电极和临床定义的治疗性DBS设置的示例模拟，以演示StimVision v2模型的一般输出。StimVision v2通过解剖详细的通路模型和电详细的电场分布，以及DBS电极位置和刺激参数设置的相互调节，提供了评估丘脑下DBS患者特异性轴突通路激活的机会。
Subthalamic deep brain stimulation (DBS) is an established therapy for Parkinson’s disease. Connectomic DBS modeling is a burgeoning subfield of research aimed at characterizing the axonal connections activated by DBS. This article describes our approach and methods for evolving the StimVision software platform to meet the technical demands of connectomic DBS modeling in the subthalamic region. StimVision v2 was developed with Visualization Toolkit (VTK) libraries and integrates four major components: 1) medical image visualization, 2) axonal pathway visualization, 3) electrode positioning, and 4) stimulation calculation. StimVision v2 implemented two key technological advances for connectomic DBS analyses in the subthalamic region. First was the application of anatomical axonal pathway models to patient-specific DBS models. Second was the application of a novel driving-force method to estimate the response of those axonal pathways to DBS. Example simulations with directional DBS electrodes and clinically defined therapeutic DBS settings are presented to demonstrate the general outputs of StimVision v2 models. StimVision v2 provides the opportunity to evaluate patient-specific axonal pathway activation from subthalamic DBS using anatomically detailed pathway models and electrically detailed electric field distributions with interactive adjustment of the DBS electrode position and stimulation parameter settings.
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影响因子：
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影响因子：
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通讯作者：
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影响因子：
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作者：
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