Effects of the mitochondria-targeted antioxidant SkQ1 on lifespan of rodents.
Effects of the mitochondria-targeted antioxidant SkQ1 on lifespan of rodents.
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DOI：
10.18632/aging.100404
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发表时间：
2011-11
期刊：
影响因子：
--
通讯作者：
Skulachev VP
中科院分区：
文献类型：
--
作者：
Anisimov VN;Egorov MV;Krasilshchikova MS;Lyamzaev KG;Manskikh VN;Moshkin MP;Novikov EA;Popovich IG;Rogovin KA;Shabalina IG;Shekarova ON;Skulachev MV;Titova TV;Vygodin VA;Vyssokikh MY;Yurova MN;Zabezhinsky MA;Skulachev VP
研究了靶向抗氧化剂SkQ 1对远系小鼠和三种近交系小鼠寿命的影响。为此，使用了彼得堡、莫斯科和斯德哥尔摩的低病原体（LP）或无特定病原体（SPF）动物园。为了比较，我们还研究了鼹鼠和侏儒仓鼠，这两种野生的小型啮齿动物在模拟自然条件下饲养。结果发现，用LP动物园代替传统（非LP）动物园，雌性远系繁殖小鼠的寿命延长了一倍，就像SkQ 1在非LP动物园中所做的那样。SkQ 1防止年龄依赖性消失的发情周期的远交系小鼠在LP和非LP动物园。在莫斯科的SPF动物园中，雄性BALB/c小鼠的寿命比雌性短，SkQ 1将其寿命延长至雌性的值。在雌性中，SkQ 1延缓了心脏质量增加等衰老特征的发展。单独圈养在斯德哥尔摩SPF动物园中的雄性C57 B1/6小鼠与雌性小鼠寿命一样长。SkQ 1增加了男性的寿命，女性的寿命不变。SkQ 1没有改变这些小鼠的食物摄入量。如果用SkQ 1处理，在室外笼子或模拟自然条件下饲养的侏儒仓鼠和鼹鼠寿命更长。SkQ 1对女性寿命的影响被认为主要是由于免疫系统的年龄相关性下降的延迟。对于LP或SPF条件下的男性，SkQ 1增加了寿命，也影响了其他一些负责衰老的系统。
The effect of the mitochondria-targeted, plastoquinone-containing antioxidant SkQ1 on the lifespan of outbred mice and of three strains of inbred mice was studied. To this end, low pathogen (LP) or specific pathogen free (SPF) vivaria in St. Petersburg, Moscow, and Stockholm were used. For comparison, we also studied mole-voles and dwarf hamsters, two wild species of small rodents kept under simulated natural conditions. It was found that substitution of a LP vivarium for a conventional (non-LP) one doubled the lifespan of female outbred mice, just as SkQ1 did in a non-LP vivarium. SkQ1 prevented age-dependent disappearance of estrous cycles of outbred mice in both LP and non-LP vivaria. In the SPF vivarium in Moscow, male BALB/c mice had shorter lifespan than females, and SkQ1 increased their lifespan to the values of the females. In the females, SkQ1 retarded development of such trait of aging as heart mass increase. Male C57Bl/6 mice housed individually in the SPF vivarium in Stockholm lived as long as females. SkQ1 increased the male lifespan, the longevity of the females being unchanged. SkQ1 did not change food intake by these mice. Dwarf hamsters and mole-voles kept in outdoor cages or under simulated natural conditions lived longer if treated with SkQ1. The effect of SkQ1 on longevity of females is assumed to mainly be due to retardation of the age-linked decline of the immune system. For males under LP or SPF conditions, SkQ1 increased the lifespan, affecting also some other system(s) responsible for aging.
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影响因子：
2.8
作者：
Agapova, L. S.;Chernyak, B. V.;Skulachev, V. P.
通讯作者：
Skulachev, V. P.
影响因子：
7.8
作者：
Andziak, Blazej;Buffenstein, Rochelle
通讯作者：
Buffenstein, Rochelle
影响因子：
5.3
作者：
Shipounova, I. N.;Svinareva, D. A.;Skulachev, V. P.
通讯作者：
Skulachev, V. P.
DOI：
10.18632/aging.100043
发表时间：
2009-04-22
期刊：
Aging
影响因子：
--
作者：
Obukhova LA;Skulachev VP;Kolosova NG
通讯作者：
Kolosova NG
影响因子：
3.7
作者：
KAPLAN, EL;MEIER, P
通讯作者：
MEIER, P