The iron chelator deferoxamine decreases myeloma cell survival.
The iron chelator deferoxamine decreases myeloma cell survival.
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DOI：
10.1177/0300060520987396
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Xu Y
中科院分区：
文献类型：
--
作者：
Yang F;Wu Z;Dai D;Zhang L;Zhang X;Zhang X;Xu Y
本研究评价了多发性骨髓瘤（MM）患者血清铁蛋白（SF）水平，并研究了其与各种临床标志物的关系。进一步研究去铁胺（DFO）对骨髓瘤细胞的作用及其分子机制。收集了84例MM患者的临床数据，以评估SF含量及其与几个重要临床参数的关系。以MM 1 S和MM 1 R骨髓瘤细胞为研究对象，探讨铁和DFO对细胞存活和凋亡的影响。在新诊断的患者中检测到SF水平升高，尤其是那些患有III期疾病或κ同种型的患者。SF含量与β2-微球蛋白、白细胞介素-6和乳酸脱氢酶表达呈正相关。此外，进行性或复发性疾病患者的SF水平较高。重要的是，铁螯合DFO有效地抑制骨髓瘤细胞的存活，并通过调节凋亡相关基因加速凋亡。强调了SF对MM的重要性。此外，DFO可能是MM的良好治疗选择。
This study evaluated serum ferritin (SF) levels and investigated their relationships with various clinical markers in patients with multiple myeloma (MM). Furthermore, the effects and molecular mechanism of deferoxamine (DFO) in myeloma cells were studied. Clinical data from 84 patients with MM were collected to evaluate SF content and its relationship with several important clinical parameters. MM1S and MM1R myeloma cells were chosen to investigate the effects of iron and DFO on cell survival and apoptosis. Increased SF levels were detected in newly diagnosed patients, especially those with stage III disease or the κ isotype. SF content was positively correlated with β2-microglobulin, interleukin-6, and lactate dehydrogenase expression. Furthermore, patients with progressive or relapsed disease had higher SF levels. Importantly, iron chelation with DFO efficiently inhibited myeloma cell survival and accelerated apoptosis by regulating apoptosis-related genes. The importance of SF for MM was highlighted. Additionally, it is suggested that DFO may be a good therapeutic option for MM.
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