The value of animal models in predicting genetic susceptibility to complex diseases such as rheumatoid arthritis.
The value of animal models in predicting genetic susceptibility to complex diseases such as rheumatoid arthritis.
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DOI：
10.1186/ar2600
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发表时间：
2009
影响因子：
4.9
通讯作者：
Holmdahl R
中科院分区：
文献类型：
--
作者：
Ahlqvist E;Hultqvist M;Holmdahl R
长期以来，复杂疾病的遗传学研究都是在动物模型中进行的。然而，遗传学领域现在正在迅速发展，人类遗传学也开始产生复杂疾病的强大候选基因。这就提出了一个问题，即如何继续在动物中寻找基因，以及如何使用动物模型来增强我们对基因功能的理解。本文就类风湿关节炎动物实验在疾病易感基因研究中的应用和优势进行综述。我们相信，动物遗传学在未来仍将是识别和研究导致疾病的途径的宝贵工具。
For a long time, genetic studies of complex diseases were most successfully conducted in animal models. However, the field of genetics is now rapidly evolving, and human genetics has also started to produce strong candidate genes for complex diseases. This raises the question of how to continue gene-finding attempts in animals and how to use animal models to enhance our understanding of gene function. In this review we summarize the uses and advantages of animal studies in identification of disease susceptibility genes, focusing on rheumatoid arthritis. We are convinced that animal genetics will remain a valuable tool for the identification and investigation of pathways that lead to disease, well into the future.