Characterization and finite element validation of transchondral strain in the human hip during static and dynamic loading.
Characterization and finite element validation of transchondral strain in the human hip during static and dynamic loading.
复制标题
静态和动态加载期间人体髋部跨软骨应变的表征和有限元验证。
DOI：
10.1016/j.jbiomech.2020.110143
复制
发表时间：
2021
影响因子：
2.4
通讯作者：
Weiss,JeffreyA
中科院分区：
文献类型：
--
作者：
Todd,JocelynN;Allan,AlexandraN;Maak,TravisG;Weiss,JeffreyA
通过关节软骨厚度的应变分布，或跨软骨应变，高度依赖于所涉及的关节的几何形状。过度的经软骨应变会破坏固体基质并最终导致骨关节炎。目前，尚不清楚人类髋关节的高分辨率跨软骨应变分布。因此，跨软骨应变模式的知识是根本的重要性，以解释发生在关节炎前髋关节损伤的模式。这项研究有三个主要目标。我们试图1）量化高分辨率的跨软骨应变在本地人髋关节，2）确定跨软骨应变之间的静态和动态加载条件下的差异，以更好地了解髋关节软骨的恢复和再加压，和3）创建有限元（FE）模型的实验测试，以验证建模框架，为未来的分析。本研究中发现的跨软骨应变模式提供了对髋关节软骨内应变定位的见解。最值得注意的是，在所有样本中，软骨盂唇连接处经历了高拉伸和剪切应变，这解释了临床数据报告其为髋关节软骨中最常见的损伤区域。此外，代表性的FE框架是能够匹配的实验静态结果和预测的动态结果非常好的协议。这种一致性为实验和计算测量方法提供了信心，并表明本研究中使用的特定各向异性双相FE框架可以描述和预测实验结果。
Distribution of strain through the thickness of articular cartilage, or transchondral strain, is highly dependent on the geometry of the joint involved. Excessive transchondral strain can damage the solid matrix and ultimately lead to osteoarthritis. Currently, high-resolution transchondral strain distribution is unknown in the human hip. Thus, knowledge of transchondral strain patterns is of fundamental importance to interpreting the patterns of injury that occur in prearthritic hip joints. This study had three main objectives. We sought to 1) quantify high-resolution transchondral strain in the native human hip, 2) determine differences in transchondral strain between static and dynamic loading conditions to better understand recovery and repressurization of cartilage in the hip, and 3) create finite element (FE) models of the experimental testing to validate a modeling framework for future analysis. The transchondral strain patterns found in this study provide insight on the localization of strain within cartilage of the hip. Most notably, the chondrolabral junction experienced high tensile and shear strain across all samples, which explains clinical data reporting it as the most common region of damage in cartilage of the hip. Further, the representative FE framework was able to match the experimental static results and predict the dynamic results with very good agreement. This agreement provides confidence for both experimental and computational measurement methods and demonstrates that the specific anisotropic biphasic FE framework used in this study can both describe and predict the experimental results.