Soluble CD163 is associated with shortened telomere length in HIV-infected patients.
Soluble CD163 is associated with shortened telomere length in HIV-infected patients.
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DOI：
10.1097/qai.0000000000000329
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发表时间：
2014-12-01
期刊：
影响因子：
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通讯作者：
Grinspoon SK
中科院分区：
文献类型：
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作者：
Srinivasa S;Fitch KV;Petrow E;Burdo TH;Williams KC;Lo J;Cȏté HCF;Grinspoon SK
对一组HIV感染者(n=102)和年龄匹配的非HIV感染者(n=41)的端粒长度(TL)和免疫激活标志物进行了测量。HIV感染者的TL明显短于非HIV感染者(P=0.04)。单因素分析显示，在HIV感染组中，TL与sCD163以及单核/巨噬细胞活化之间存在强烈的负相关关系(ρ=−为0.30，P=0.003)。在全组多因素模型中，HIV阳性血清状态(P=0.06)和sCD163(P=0.05)是TL控制年龄和吸烟状况的独立预测因素。我们的数据表明，增强的免疫活性与HIV中较短的TL有关。
Telomere length (TL) and immune activation markers were measured in a cohort of HIV-infected (n=102) and age-matched non-HIV-infected (n=41) men. TL was significantly shorter in HIV-infected compared to non-HIV-infected subjects (P = 0.04). Univariate analysis revealed a strong inverse relationship of TL to sCD163, and thus, monocyte/macrophage activation, among the HIV group (ρ = −0.30, P = 0.003). In multivariate modeling among the whole group, HIV positive serostatus (P = 0.06) and sCD163 (P = 0.05) were independent predictors of TL controlling for age and smoking status. Our data demonstrate that increased immune activation relates to shorter TL in HIV.