Ex vivo cortical porosity and thickness predictions at the tibia using full-spectrum ultrasonic guided-wave analysis
Ex vivo cortical porosity and thickness predictions at the tibia using full-spectrum ultrasonic guided-wave analysis
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DOI：
10.1007/s11657-019-0578-1
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发表时间：
2019-02
影响因子：
3
通讯作者：
J. Schneider;G. Iori;Donatien Ramiandrisoa;Maroua Hammami;M. Gräsel;C. Chappard;R. Barkmann;P. Laugier;Q. Grimal;J. Minonzio;K. Raum
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文献类型：
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作者：
J. Schneider;G. Iori;Donatien Ramiandrisoa;Maroua Hammami;M. Gräsel;C. Chappard;R. Barkmann;P. Laugier;Q. Grimal;J. Minonzio;K. Raum
总结使用轴向传输超声对胫骨皮质厚度（Ct.Th）和孔隙度（Ct.Po）的估计成功地通过与部位匹配的微型计算机断层扫描进行了体外验证。基于全频谱导波分析的皮质参数评估可能会提高骨折的预测在一个成本效益和无辐射manning.PurposeCortical厚度（Ct.Th）和孔隙度（Ct.Po）的关键参数识别患者的脆弱骨。本离体研究的主要目的是验证使用非电离、低成本和便携式500 kHz超声轴向传输系统测量胫骨的Ct.Po和Ct.Th。额外的超声波速度和网站匹配的参考参数包括在研究中，以扩大analysis.MethodsGuided波成功地测量离体在17人tibons使用一种新型的500 kHz的双向轴向传输探头。将具有不变基体刚度的横观各向同性自由板模型的理论频散曲线与实验频散曲线进行拟合，以估计Ct.Th和Ct. Po。此外，还测量了最早到达信号（FAS）和A0模（A0）的速度。参考Ct.Po、Ct.Th和vBMD从位点匹配的微型计算机断层扫描获得。扫描声学显微镜（SAM）提供的声阻抗的轴向皮质骨matrix.ResultsThe最好的预测Ct.Po（R2= 0.83，RMSE = 2.2%）和Ct.Th（R2= 0.92，RMSE = 0.2 mm，排除一个离群值）从板模型。第二个最好的预测Ct.Po和Ct.Th werevBMD（R2= 0.77，RMSE = 2.6%）和BMD A0（R2= 0.28，RMSE = 0.67 mm），foreign.ConclusionsCt.Th和Ct.Po准确预测在人体胫骨离体使用横向各向同性自由板模型与不变的矩阵刚度。当我们考虑到SAM声阻抗所反映的轴向组织刚度变化时，基于模型的预测没有进一步增强。
SummaryThe estimation of cortical thickness (Ct.Th) and porosity (Ct.Po) at the tibia using axial transmission ultrasound was successfully validated ex vivo against site-matched micro-computed tomography. The assessment of cortical parameters based on full-spectrum guided-wave analysis might improve the prediction of bone fractures in a cost-effective and radiation-free manner.PurposeCortical thickness (Ct.Th) and porosity (Ct.Po) are key parameters for the identification of patients with fragile bones. The main objective of this ex vivo study was to validate the measurement of Ct.Po and Ct.Th at the tibia using a non-ionizing, low-cost, and portable 500-kHz ultrasound axial transmission system. Additional ultrasonic velocities and site-matched reference parameters were included in the study to broaden the analysis.MethodsGuided waves were successfully measured ex vivo in 17 human tibiae using a novel 500-kHz bi-directional axial transmission probe. Theoretical dispersion curves of a transverse isotropic free plate model with invariant matrix stiffness were fitted to the experimental dispersion curves in order to estimate Ct.Th and Ct.Po. In addition, the velocities of the first arriving signal (υFAS) and A0mode (υA0) were measured. Reference Ct.Po, Ct.Th, andvBMDwere obtained from site-matched micro-computed tomography. Scanning acoustic microscopy (SAM) provided the acoustic impedance of the axial cortical bone matrix.ResultsThe best predictions of Ct.Po (R2= 0.83, RMSE = 2.2%) and Ct.Th (R2= 0.92, RMSE = 0.2 mm, one outlier excluded) were obtained from the plate model. The second best predictors of Ct.Po and Ct.Th werevBMD(R2= 0.77, RMSE = 2.6%) andυA0(R2= 0.28, RMSE = 0.67 mm), respectively.ConclusionsCt.Th and Ct.Po were accurately predicted at the human tibia ex vivo using a transverse isotropic free plate model with invariant matrix stiffness. The model-based predictions were not further enhanced when we accounted for variations in axial tissue stiffness as reflected by the acoustic impedance from SAM.