8α‐substituted flavins of biological importance: An updating
8α‐substituted flavins of biological importance: An updating
复制标题
具有生物学重要性的 8α 取代黄素：更新
DOI：
10.1016/0014-5793(76)80305-5
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发表时间：
1976
期刊：
影响因子：
3.5
通讯作者：
T. Singer
中科院分区：
文献类型：
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作者：
D. Edmondson;T. Singer
自从我们写了一封关于这个主题的评论信以来，在过去的两年里，8 Cr-取代的黄素领域的进展是如此迅速，以至于对主要的新进展进行简要总结似乎是可取的。此外，更新我们的评论函是及时的，因为第四类共价结合的黄素的结构，以前被认为是8 o-AQistidyl-8a-羟基核黄素，刚刚被最终确定为8 o-[N（1）-histidyl]-核黄素[2]，这反过来又需要修改早期关于酸对8a-[N（3）-histidyl]-核黄素影响的想法。此外，一些有趣的应用积累的知识covalentlybound黄素最近已被报道。本文旨在提请注意这些事态发展。然而，这只是对我们以前的评论[1]的补充，在整个过程中都会提到它，读者可以参考它来系统地报道这个领域，而这个领域的发展历史已经在其他地方进行了调查[3]。
In the two years which have passed since we wrote a review letter on this subject [l] advances in the field of 8cr-substituted flavins have been so rapid that a brief summary of major new developments seems desirable. Updating of our review letter is timely, moreover, because the structure of the fourth class of covalently-bound flavins, previously thought to be 8o-AQistidyl-8a-hydroxyriboflavin, has just been conclusively identified as 8o-[iV (1) histidyl]-riboflavin [2] and this, in turn, necessitates revision of earlier ideas on the influence of acid on 8a-[N (3)-histidyl]-riboflavin. Further, a number of interesting applications of accrued knowledge concerning covalentlybound flavins have been reported very recently. The present article is intended to call attention to these developments. It is only a supplement to our previous review [1], however, to which reference will be made throughout, and to which the reader is referred for a systematic coverage of the field, while the history of the development of the field has been surveyed elsewhere [3].