The role of circulating IL-8 and VEGF protein in the progression of gastric cancer
The role of circulating IL-8 and VEGF protein in the progression of gastric cancer
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DOI：
10.1111/j.1349-7006.2003.tb01511.x
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发表时间：
2003-08-01
期刊：
影响因子：
5.7
通讯作者：
Nakamura, S
中科院分区：
文献类型：
--
作者：
Konno, H;Ohta, M;Nakamura, S
血管内皮生长因子（VEGF）和白细胞介素8（IL-8）在胃癌的发生、发展中起重要作用。在这项研究中，我们调查了胃癌患者引流静脉中VEGF或IL-8的循环水平是否与任何临床病理因素相关。我们分析了1999年至2002年间在我科行胃切除术的37例原发性胃癌患者。在手术前从外周静脉和剖腹手术后立即从引流静脉抽取血样。血浆VEGF水平显著高于10名健康对照。引流静脉中的VEGF水平与任何clink copathological变量之间没有相关性，而外周静脉中的VEGF水平则存在显著相关性;静脉浸润患者的VEGF水平更高。我们发现引流静脉中IL-8水平与肿瘤大小和淋巴结转移显著相关，而外周静脉中IL-8水平与任何变量均无显著相关性，引流静脉中VEGF和IL-8水平无相关性。尽管多变量分析显示淋巴结受累是唯一的独立预后因素，但大肿瘤、深度浸润性肿瘤、淋巴结受累、静脉浸润和引流静脉中高IL-8水平均与较短的无病生存期显著相关。总之，测量GC患者引流静脉中的IL-8水平可能主要反映原发病变的产生，并且作为疾病复发风险的指标是有价值的。
Both vascular endothelial growth factor (VEGF) and interleukin 8 (IL-8) play an important role in the progression of gastric cancer (GC). In this study, we investigated whether circulating levels of VEGF or IL-8 in drainage veins of GC patients were correlated with any clinicopathological factors. Thirty-seven patients with primary GC who underwent gastrectomy at our department between 1999 and 2002 were analyzed. Blood samples were drawn from a peripheral vein just before surgery and from a drainage vein immediately after laparotomy. Plasma VEGF levels were significantly higher than those in 10 healthy controls. There was no correlation between VEGF levels in drainage veins and any clink copathological variable, whereas there was a significant relationship in the case of VEGF levels in peripheral veins; the levels were higher in patients with venous invasion. We found a significant relationship between IL-8 levels in drainage veins and both tumor size and lymph node metastasis, whereas no significant relationship between IL-8 levels in peripheral veins and any variable was found. There was no correlation between VEGF and IL-8 levels in drainage veins. Large tumors, deeply invasive tumors, lymph node involvement, venous invasion and high IL-8 levels in drainage veins were all significantly associated with shorter disease-free survival, although multivariate analysis revealed that lymph node involvement was the only independent prognostic factor. In conclusion, the measurement of IL-8 levels in drainage veins of GC patients may reflect production mainly by the primary lesion and is valuable as an indicator of risk for recurrent disease.