Neuropathologic findings in the acquired immunodeficiency syndrome (AIDS).
Neuropathologic findings in the acquired immunodeficiency syndrome (AIDS).
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DOI：
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发表时间：
1986
影响因子：
1.1
通讯作者：
Karl H. Anders;K. Steinsapir;Iverson Dj;B. J. Glasgow;L. Layfield;Brown Wj;P. Cancilla;M. Verity;H. V. Vinters
中科院分区：
文献类型：
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作者：
Karl H. Anders;K. Steinsapir;Iverson Dj;B. J. Glasgow;L. Layfield;Brown Wj;P. Cancilla;M. Verity;H. V. Vinters
获得性免疫缺陷综合征(AIDS)的特点是T细胞介导的免疫功能严重缺乏。同性恋者、静脉吸毒者和海地人主要受到影响，使他们容易受到机会性感染和肿瘤的影响。本研究对29例艾滋病患者的中枢神经系统(CNS)进行尸检。显著的中枢神经系统并发症发生在55%，主要与机会性感染有关，类似于其他免疫抑制原因的患者。进行性多灶性白质脑病3例，巨细胞病毒脑炎5例，隐球菌性脑膜炎4例，细胞内分枝杆菌3例，弓形虫病1例。在20名患者中观察到广泛的小胶质结节，其中80%在尸检时在其他地方有巨细胞病毒包涵体。原发性脑淋巴瘤(1例)和淋巴瘤样肉芽肿(1例)。蛛网膜下腔出血(5例)和脑实质内出血(3例)，尽管临床上通常不明显。1例动脉栓塞性梗阻合并皮质梗塞是由非细菌性血栓性心内膜炎引起的。
The acquired immunodeficiency syndrome (AIDS) is characterized by a severe idiopathic deficiency in T-cell mediated immunity. Homosexuals, intravenous drug abusers and Haitians are predominantly affected, predisposing them to opportunistic infections and neoplasms. In this study, the central nervous system (CNS) was examined at autopsy in 29 AIDS patients. Significant CNS complications occurred in 55%, mainly related to opportunistic infections similar to those seen in patients with other causes of immunosuppression. Progressive multifocal leukoencephalopathy (three cases), cytomegalovirus (CMV) encephalitis (five cases), cryptococcal meningitis (four cases), Mycobacterium avium-intracellulare (three cases), and toxoplasmosis (one case) were found. Widespread microglial nodules were observed in 20 patients, 80% of whom had CMV inclusions elsewhere at autopsy. Primary cerebral lymphoma (one case) and lymphomatoid granulomatosis (one case) were present. Subarachnoid (five cases) and intraparenchymal (three cases) hemorrhage was seen although these were not usually clinically significant. A single case of embolic arterial obstruction with cortical infarction was due to non-bacterial thrombotic endocarditis.