Immunohistochemical characterization of appendiceal mucinous neoplasms and the value of special AT‐rich sequence‐binding protein 2 in their distinction from primary ovarian mucinous tumours
Immunohistochemical characterization of appendiceal mucinous neoplasms and the value of special AT‐rich sequence‐binding protein 2 in their distinction from primary ovarian mucinous tumours
复制标题
阑尾粘液性肿瘤的免疫组织化学特征以及特殊富含 AT 的序列结合蛋白 2 在与原发性卵巢粘液性肿瘤的区分中的价值
DOI：
10.1111/his.12899
复制
发表时间：
2016
期刊：
影响因子：
6.4
通讯作者：
C. Parra‐Herran
中科院分区：
文献类型：
--
作者：
S. Strickland;C. Parra‐Herran
原发性卵巢粘液性肿瘤和转移到卵巢的阑尾粘液性肿瘤之间的区别可能是具有挑战性的，因为传统标记物的形态学特征和免疫组化表达重叠。特殊的富含AT的序列结合蛋白2（SATB 2）最近被描述为结直肠上皮的敏感和特异性标志物。本研究旨在确定其在卵巢粘液性肿瘤中的表达及其在与卵巢肿瘤区分中的作用。
The distinction between primary ovarian mucinous tumours and appendiceal mucinous neoplasms metastatic to the ovary can be challenging, given the overlap of morphological features and immunohistochemical expression of traditional markers. Special AT‐rich sequence‐binding protein 2 (SATB2) has recently been described as a sensitive and specific marker of colorectal epithelium. This study was to determine its expression in appendiceal mucinous tumours and its role in their distinction from ovarian neoplasms.