Early menopause in women with Down's syndrome.
Early menopause in women with Down's syndrome.
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患有唐氏综合症的女性会提前绝经。
DOI：
10.1111/j.1365-2788.1997.tb00706.x
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
Levin,B
中科院分区：
文献类型：
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作者：
Schupf,N;Zigman,W;Kapell,D;Lee,JH;Kline,J;Levin,B
我们使用AAMR的适应行为量表来确定157名患有唐氏综合症（DS）的女性和187名患有其他智力残疾的女性的当前月经状况，这些女性的年龄都在40岁或以上。经年龄调整后，患有退行性椎体滑移综合征的女性绝经的可能性是患有其他智力残疾的女性的两倍（OR=2.3; 95% Cl= 1.1 - 4,9）。经治疗的甲状腺疾病不影响月经状况，也不改变DS和月经状况之间的关系。这些发现支持了一种假设，即患有退行性痴呆的女性更年期提前，这可能与衰老加速有关。
We used the AAMR's Adaptive Behavior Scale to ascertain current menstrual status in a population‐based sample of 157 women with Down's syndrome (DS) and 187 women with other intellectual disability, all 40 years of age or older. The age‐adjusted likelihood of menopause was twice as high in women with DS syndrome as in women with other intellectual disability (OR=2.3; 95% Cl= 1.1–4,9). Treated thyroid conditions did not influence menstrual status and did not modify the relationship between DS and menstrual status. These findings support the hypothesis that women with DS experience menopause at an earlier age and that this may be associated with accelerated aging.