The BCPT symptom scales: A measure of physical symptoms for women diagnosed with or at risk for breast cancer
The BCPT symptom scales: A measure of physical symptoms for women diagnosed with or at risk for breast cancer
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DOI：
10.1093/jnci/dji069
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发表时间：
2005-03-16
影响因子：
10.3
通讯作者：
Ganz, PA
中科院分区：
文献类型：
--
作者：
Stanton, AL;Bernaards, CA;Ganz, PA
背景。记录预防和治疗乳腺癌的医疗干预措施的并发和晚期副作用在研究和临床实践中非常重要。我们使用乳腺癌预防试验 (BCPT) 症状检查表开发了一种工具（BCPT 症状量表），可用于评估副作用并检查患者群体中衍生症状维度的相关性。方法：使用 42 项 BCPT 症状检查表中的数据进行探索性和验证性因素分析，该检查表由四个不同的患者群体 (N = 2208) 完成，这些患者群体先前被诊断患有乳腺癌或有患该疾病的风险。我们研究了由此产生的 BCPT 症状量表与人口统计和癌症相关变量以及广泛使用的健康相关生活质量指标之间的关联。结果：探索性和验证性因素分析揭示了与癌症治疗、化学预防、更年期和正常衰老相关的身体症状对应的八个因素：潮热、恶心、膀胱控制、阴道问题、肌肉骨骼疼痛、认知问题、体重问题和手臂问题。在衍生的 BCPT 症状量表中，女性报告的潮热、疼痛和体重问题的平均分高于其他症状的量表。人口统计和癌症相关变量占女性对症状量表反应方式的个体间差异的 15%。报告更严重症状的最一致的预测因素包括较低的教育水平和之前接受过化疗。结论：在四个女性样本中确定的有意义的症状维度与人口统计学和乳腺癌相关变量相关。 BCPT 症状量表对原始 BCPT 症状检查表进行了有价值的改进，以评估与乳腺癌治疗和预防相关的副作用。
Background. Documentation of concurrent and late side effects of medical interventions to prevent and treat breast cancer is important in research and clinical practice. We used the Breast Cancer Prevention Trial (BCPT) Symptom Checklist to develop an instrument (BCPT Symptom Scales) that could be used to assess side effects and to examine correlates of the derived symptom dimensions among patient populations. Methods: Exploratory and confirmatory factor analyses were conducted using data from the 42-item BCPT Symptom Checklist completed by four distinct patient populations (N = 2208) who had previously been diagnosed with breast cancer or were at risk for the disease. We examined associations among the resulting BCPT Symptom Scales and demographic and cancer-related variables and a widely used measure of health-related quality of life. Results: Exploratory and confirmatory factor analyses revealed eight factors corresponding to physical symptoms associated with cancer treatment, chemoprevention, menopause, and normal aging: hot flashes, nausea, bladder control, vaginal problems, musculoskeletal pain, cognitive problems, weight problems, and arm problems. On the derived BCPT Symptom Scales, women reported somewhat higher mean scores on scales for hot flashes, pain, and weight problems than on scales for the other symptoms. Demographic and cancer-related variables accounted for up to 15% of the interindividual variance in how women responded to the symptom scales. The most consistent predictors of reporting greater symptoms included lower education level and previous receipt of chemotherapy. Conclusions: Meaningful symptom dimensions, identified across four samples of women, were associated with demographic and breast cancer-related variables. The BCPT Symptom Scales offer a valuable refinement of the original BCPT Symptom Checklist to assess side effects associated with the treatment and prevention of breast cancer.