Endothelial Cells in the Tumor Microenvironment
Endothelial Cells in the Tumor Microenvironment
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DOI：
10.1007/978-3-030-37184-5_6
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发表时间：
2020-01-01
期刊：
影响因子：
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通讯作者：
Niewiarowska, Jolanta
中科院分区：
文献类型：
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作者：
Sobierajska, Katarzyna;Ciszewski, Wojciech Michal;Niewiarowska, Jolanta
血管生成是肿瘤进展所需的关键过程。新形成的血管为肿瘤提供营养和氧气，促进其生长和发育。然而，内皮还发挥其他促进肿瘤转移的功能。它参与血管内渗，使侵入性癌细胞转移到血管腔中。这种现象是癌症转移的重要阶段。除了与癌症发展直接相关外，内皮细胞是癌症相关成纤维细胞（CAF）的主要来源之一。CAFs的异质性是癌细胞迁移和侵袭能力的主要诱导因子。因此，内皮也间接地负责转移。因此，内皮细胞是肿瘤治疗的重要靶点之一。在本章中，我们将介绍调节内皮功能的机制，依赖于癌症和癌症小生境细胞。我们将重点关注在抗癌治疗中应用的抑制促转移内皮功能的可能性。
Angiogenesis is a critical process required for tumor progression. Newly formed blood vessels provide nutrition and oxygen to the tumor contributing to its growth and development. However, endothelium also plays other functions that promote tumor metastasis. It is involved in intravasation, which allows invasive cancer cells to translocate into the blood vessel lumen. This phenomenon is an important stage for cancer metastasis. Besides direct association with cancer development, endothelial cells are one of the main sources of cancer-associated fibroblasts (CAFs). The heterogeneous group of CAFs is the main inductor of migration and invasion abilities of cancer cells. Therefore, the endothelium is also indirectly responsible for metastasis. Considering the above, the endothelium is one of the important targets of anticancer therapy. In the chapter, we will present mechanisms regulating endothelial function, dependent on cancer and cancer niche cells. We will focus on possibilities of suppressing pro-metastatic endothelial functions, applied in anti-cancer therapies.