(S)-(+)-Ibuprofen-based hydrogelators:: an approach toward anti-inflammatory drug delivery
(S)-(+)-Ibuprofen-based hydrogelators:: an approach toward anti-inflammatory drug delivery
复制标题
DOI：
10.1016/j.tetlet.2006.08.002
复制
发表时间：
2006-10-02
影响因子：
1.8
通讯作者：
Kim, Byeang Hyean
中科院分区：
文献类型：
--
作者：
Bhuniya, Sankarprasad;Seo, Young Jun;Kim, Byeang Hyean
我们合成了具有二肽连接功能的(S)-(+)-布洛芬水凝胶。在水介质中，其中一种水凝胶剂形成了坚固的凝胶，可以稳定几个月。酶介导的水解为这种抗炎剂的持续释放提供了一条途径。(C)2006爱思唯尔有限公司。保留所有权利。
We have synthesized (S)-(+)-ibuprofen-based hydrogelators that feature dipeptide linkages. In aqueous media, one of these hydrogelators formed robust gels that were stable for several months. Enzyme-mediated hydrolysis offers a route toward the sustained release of this anti-inflammatory agent. (c) 2006 Elsevier Ltd. All rights reserved.