Lifetime cognitive performance is associated with midlife physical performance in a prospective national birth cohort study.
Lifetime cognitive performance is associated with midlife physical performance in a prospective national birth cohort study.
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DOI：
10.1097/psy.0b013e31818a1620
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发表时间：
2009-01
影响因子：
3.3
通讯作者：
Musculoskeletal Study Team
中科院分区：
文献类型：
--
作者：
Kuh D;Cooper R;Hardy R;Guralnik J;Richards M;Musculoskeletal Study Team
考虑到潜在的混杂因素，检查一生中的认知表现指标是否与53岁时的身体表现相关。在一个大型的代表性英国男性和女性出生队列（N=2135）中，研究了整个生命周期的认知表现（即15岁，43岁和53岁的标准化认知评分以及43岁至53岁之间的言语记忆和搜索速度评分的变化）与53岁时的身体表现（即站立平衡，椅子上升和握力）之间的相关性。对53岁时的体型、体力活动水平、健康状况和社会经济条件进行了调整。在所有儿童和成人测试中，较高的认知得分，以及言语记忆和搜索速度的缓慢下降，与更好的站立平衡有关。更高的语言流畅性分数和更慢的语言记忆和搜索速度的下降比一般认知能力测试的分数更强相关椅子上升。认知表现与握力之间的关系不一致和弱。发现的差异关联模式与每种模式依赖于中枢神经系统功能的程度一致。我们的研究结果表明，最初的发展差异以及共同的衰老过程可能是认知和身体表现之间的关联的基础。
To examine whether measures of cognitive performance across life are related to physical performance at age 53y, allowing for potential confounders. In a large representative British birth cohort of men and women (N=2135) the associations between cognitive performance across life (i.e. standardised cognition scores at ages 15, 43 and 53y and changes in verbal memory and search speed scores between 43 and 53y) and measures of physical performance at age 53y (i.e. standing balance, chair rising and grip strength) were examined. Adjustments were made for body size, physical activity levels, health status and socioeconomic conditions at age 53y. Higher cognitive scores on all childhood and adult tests, and a slower decline in verbal memory and search speed, were associated with better standing balance. Higher verbal fluency scores and a slower decline in verbal memory and search speed were more strongly related than scores on tests of general cognitive ability to chair rising. The relationships between cognitive performance and grip strength were inconsistent and weak. The differential patterns of association found are consistent with the degree to which each is dependent upon central nervous system function. Our findings suggest that initial developmental differences as well as shared ageing processes may underlie associations found between cognitive and physical performance.