Bilateral internuclear ophthalmoplegia from doxepin overdose
Bilateral internuclear ophthalmoplegia from doxepin overdose
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多虑平过量导致双侧核间性眼肌麻痹
DOI：
10.1212/wnl.34.2.259
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发表时间：
1984
期刊：
影响因子：
9.9
通讯作者：
Steven P. Donhowe
中科院分区：
文献类型：
--
作者：
Steven P. Donhowe
致编辑：在他们有趣的文章中，Duvoisin博士等人都指出，培高利特在治疗晚期帕金森病患者时可能比溴隐亭更有效，因为培高利特的作用对突触前多巴胺能成分的依赖性要小得多。作者得出后一结论的依据是，在用N-甲基-对酪氨酸预处理后，用培高利特处理的大鼠比用溴隐亭处理的大鼠继续具有更强的循环活动。虽然这些结果令人印象深刻，但我怀疑它们是否反映了任何潜在的生理特性，而不仅仅是药理学操作。作者指出，0.25 mg/kg培高利特的效力至少是1.0 mg/kg溴隐亭的4倍。可能的情况是，如果作者在N-甲基-对酪氨酸实验中测试了这些药剂的等效剂量，则两组动物的反应将相似。
To the Editor: In their interesting article, Dr. Duvoisin et all make the point that pergolide may be more effective than bromocriptine in treating patients with advanced Parkinson's disease, because pergolide was much less dependent on presynaptic dopaminergic elements for its effect. The authors based this latter conclusion on the observation that after pretreatment with alphamethyl-paratyrosine, rats treated with pergolide continued to have more circlingactivity than those treated with bromocriptine. Although these results were impressive, I question whether they reflect any underlying physiologic property rather than merely a pharmacologic manipulation. The authors state that the dosage of 0.25 mg/kg pergolide is a t least four times more potent than 1.0 mg/kg bromocriptine. It may be the case that if the authors had tested equipotent doses of these agents in the alphamethyl-paratyrosine experiment, the responses of the animals in the two groups would have been similar.
视觉屏状体：猫的地形和感受野特性。
DOI：
10.1126/science.7209525
发表时间：
1981
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Sherk,H;LeVay,S
通讯作者：
LeVay,S