A role for CNS alpha-2 adrenergic receptors in opiate-induced muscle rigidity in the rat.
A role for CNS alpha-2 adrenergic receptors in opiate-induced muscle rigidity in the rat.
复制标题
CNS α-2 肾上腺素能受体在阿片类药物引起的大鼠肌肉僵硬中的作用。
DOI：
10.1016/0006-8993(94)01216-5
复制
发表时间：
1995
期刊：
影响因子：
2.9
通讯作者：
Smith,NT
中科院分区：
文献类型：
--
作者：
Weinger,MB;Chen,DY;Lin,T;Lau,C;Koob,GF;Smith,NT
A number of potential neurochemical mediators of opiate-induced muscle rigidity have been proposed based on the results of systemic drug studies and on knowledge of the brain sites implicated in opiate rigidity. The effects of i.c.v. pretreatment with selected opioidergic, α adrenergic and serotonergic drugs on muscle rigidity induced with systemic injection of the potent opiate agonist alfentanil (ALF) were investigated in spontaneously ventilating rats. The opiate antagonist methylnaloxonium (MN; 0.2–14 nmol), α-2 adrenergic agonists dexmedetomidine (DEX; 0.4–42 nmol) or 2-(2,6-diethylphenylamino)-2-imidazoline hydrochloride (ST91; 4–400 nmol), α-1 adrenergic antagonist prazosin (PRZ; 7–70 nmol) or serotonergic antagonist ketanserin (KET; 18–550 nmol) were injected i.c.v. (10 μl) and ALF (500 μg/kg s.c.) was administered 10 min later. S.c. electrodes were used to record gastrocnemius electromyographic activity. Both MN and DEX dose-dependently and potently antagonized ALF-induced rigidity. ST91 produced shorter-lived, less profound, antagonism of ALF rigidity. PRZ, at the highest dose tested, produced a delayed and modest reduction in ALF rigidity. A large, non-selective, dose of KET incompletely attenuated ALF rigidity. These results lend support to the hypothesis that central opioid and α-2 adrenergic receptors mediate opiate-induced muscle rigidity in the rat.
