Improved opioid analgesic effect following opioid dose reduction.
Improved opioid analgesic effect following opioid dose reduction.
复制标题
减少阿片类药物剂量后改善阿片类药物镇痛效果。
DOI：
10.1111/j.1526-4637.2008.00501.x
复制
发表时间：
2008
期刊：
影响因子：
3.1
通讯作者：
J. Mao
中科院分区：
文献类型：
--
作者：
Yakov Vorobeychik;Lucy L. Chen;M. C. Bush;J. Mao
INTRODUCTION
Traditionally, opioids have been the cornerstone of therapy for patients suffering from cancer pain, regardless of the potential to develop opioid tolerance. In chronic pain patients who experience worsening pain despite increasing doses of opioids, the clinical role of opioid-induced hyperalgesia is gaining more recognition.
CASE
Presented here is the case of a 56-year-old man with recurrent squamous cell lung carcinoma and spinal metastases, suffering with intractable 8/10 pain on the visual analog scale in his chest, lower thoracic spine, and upper lumbar spine. He was admitted five times for pain control. In spite of escalating doses of oxycodone, morphine, and hydromorphone, the patient continued to experience severe pain. Also, he endured undesirable sedation, fatigue, and generalized weakness. The clinical picture suggested the possibility of opioid-induced hyperalgesia. We decreased the hydromorphone dose by 40-50% and started methadone. The patient's pain level dropped to a more acceptable 3/10. He was more alert, and his pain was tolerable until his death.
DISCUSSION
Opioid-induced hyperalgesia might be considered in a patient who has no evidence of disease progression, who is on clinically reasonable doses of opioids, and whose pain escalates as opioid doses are increased. A reduction of opioids and the addition of a low-dose N-methyl-D-aspartate receptor antagonist may provide a favorable clinical outcome in those patients who have failed to benefit from opioid rotation and other adjunctive pain treatments.
慢性吗啡暴露会增加大鼠延髓头端腹内侧on-细胞的比例。
影响因子：
6.1
作者：
Meng,IanD;Harasawa,Ichiro
通讯作者：
Harasawa,Ichiro