Antibacterial Adhesion of Poly(methyl methacrylate) Modified by Borneol Acrylate
Antibacterial Adhesion of Poly(methyl methacrylate) Modified by Borneol Acrylate
复制标题
丙烯酸冰片改性聚甲基丙烯酸甲酯的抗菌附着力
DOI：
10.1021/acsami.6b10498
复制
发表时间：
2016-10-26
影响因子：
9.5
通讯作者：
Wang, Xing
中科院分区：
文献类型：
--
作者：
Sun, Xueli;Qin, Zhiyong;Wang, Xing
聚甲基丙烯酸甲酯（PMMA）是一种广泛应用的生物材料。但其不必要的细菌粘附仍然面临挑战，因为随后的生物膜形成通常导致相关植入物失败。在此，我们提出了一种基于简单有效的立体化学策略的醇改性PMMA，生成抗菌共聚物P（MMA-co-BA）。采用自由基聚合法合成了甲基丙烯酸甲酯（MMA）和丙烯酸丁酯（BA）单体，并对其进行了研究。NMR、GPC和EA等，用来确认它们的化学特征他们的薄膜受到大肠杆菌（革兰氏阴性）和枯草杆菌（革兰氏阳性）的挑战，显示出BA含量依赖性的抗菌性能。最小有效剂量应为10%。然后通过常规组织切片和HE染色证实了它们在小鼠体内的生物相容性。因此，P（MMA-co-BA）不仅表现出其独特的抗菌特性，而且还表明了对苯二酚改性的PMMA的安全使用的潜力。用于进一步植入的框架和装置。
Poly(methyl methacrylate) (PMMA) is a widely used biomaterial. But there is still a challenge facing its unwanted bacterial adhesion because the subsequent biofilm formation usually leads to failure of related implants. Herein, we present a borneol-modified PMMA based on a facile and effective stereochemical strategy, generating antibacterial copolymer named as P(MMA-co-BA). It was synthesized by free radical polymerization and studied with different ratio between methyl methacrylate (MMA) and borneol acrylate (BA) monomers. NMR, GPC, and EA, etc., were used to confirm their chemical features. Their films were challenged with Escherichia coli (Gram-negative) and Bacillus subtilis (Gram-positive), showing a BA content dependent antibacterial performance. The minimum effective dose should be 10%. Then in vivo subcutaneous implantations in mice demonstrated their biocompatibilities through routine histotomy and HE staining. Therefore, P(MMA-co-BA)s not only exhibited their unique antibacterial character but also suggested a potential for the safe usage of borneol-modified PMMA. frame and devices for further implantation.