The Role of Actin Dynamics and Actin-Binding Proteins Expression in Epithelial-to-Mesenchymal Transition and Its Association with Cancer Progression and Evaluation of Possible Therapeutic Targets.
The Role of Actin Dynamics and Actin-Binding Proteins Expression in Epithelial-to-Mesenchymal Transition and Its Association with Cancer Progression and Evaluation of Possible Therapeutic Targets.
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DOI：
10.1155/2018/4578373
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发表时间：
2018
影响因子：
--
通讯作者：
Gagat M
中科院分区：
文献类型：
--
作者：
Izdebska M;Zielińska W;Grzanka D;Gagat M
转移导致90%的癌症患者死亡，因此它是与癌症疾病相关的最重要的问题。因此，许多研究人员试图开发针对或预防它们的药物也就不足为奇了。继发性肿瘤部位的形成与上皮-间质及其反向的间质-上皮转变等现象密切相关。细胞表型向间充质的转变涉及迁移潜力的获得。由于侵入性伪足、板状伪足和丝状伪足等侵入性结构的发展，癌细胞的运动成为可能。这些变化取决于肌动蛋白细胞骨架的重组。反过来，肌动蛋白的聚合和解聚由肌动蛋白结合蛋白控制。在许多肿瘤细胞中，肌动蛋白和肌动蛋白相关蛋白在细胞核中积累，这表明它也可能通过调节基因表达来影响癌症的进展。一旦癌细胞到达新的栖息地，它就会再次获得上皮特征，从而具有增殖活性。通过调节其主要成分表达来靶向上皮-间质或/和间质-上皮转变可能是转移问题的潜在解决方案。这项工作的重点是这些过程在肿瘤进展中的作用以及针对它们的药物的治疗潜力的评估。
Metastasis causes death of 90% of cancer patients, so it is the most significant issue associated with cancer disease. Thus, it is no surprise that many researchers are trying to develop drugs targeting or preventing them. The secondary tumour site formation is closely related to phenomena like epithelial-to-mesenchymal and its reverse, mesenchymal-to-epithelial transition. The change of the cells' phenotype to mesenchymal involves the acquisition of migratory potential. Cancer cells movement is possible due to the development of invasive structures like invadopodia, lamellipodia, and filopodia. These changes are dependent on the reorganization of the actin cytoskeleton. In turn, the polymerization and depolymerization of actin are controlled by actin-binding proteins. In many tumour cells, the actin and actin-associated proteins are accumulated in the cell nucleus, suggesting that it may also affect the progression of cancer by regulating gene expression. Once the cancer cell reaches a new habitat it again acquires epithelial features and thus proliferative activity. Targeting of epithelial-to-mesenchymal or/and mesenchymal-to-epithelial transitions through regulation of their main components expression may be a potential solution to the problem of metastasis. This work focuses on the role of these processes in tumour progression and the assessment of therapeutic potential of agents targeting them.
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影响因子：
64.5
作者：
Drees, F;Pokutta, S;Weis, WI
通讯作者：
Weis, WI
缺氧会增强乳腺癌中的 Notch 信号传导，导致 E-钙粘蛋白表达减少，细胞迁移和侵袭增加。
影响因子：
8.8
作者：
Chen, J.;Imanaka, N.;Chen, J.;Griffin, J. D.
通讯作者：
Griffin, J. D.
影响因子：
11.2
作者：
Chaffer, Christine L.;Brennan, Janelle P.;Williams, Elizabeth D.
通讯作者：
Williams, Elizabeth D.
影响因子：
7.8
作者：
Brock, J;Midwinter, K;Martin, P
通讯作者：
Martin, P
影响因子：
5.4
作者：
Gagat, Maciej;Grzanka, Dariusz;Grzanka, Alina
通讯作者：
Grzanka, Alina