A TAD closer to ATM.
A TAD closer to ATM.
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DOI：
10.1080/23723556.2015.1134411
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发表时间：
2016-05
影响因子：
2.1
通讯作者：
Legube G
中科院分区：
文献类型：
--
作者：
Aymard F;Legube G
共济失调毛细血管扩张突变（ATM）作为介导DNA双链断裂反应的主要激酶已被人们所知。我们最近的研究结果表明，它在断裂部位的主要作用可能在于它能够改变局部染色质景观和整体染色体组织，以促进修复的准确性。
Ataxia telangiectasia mutated (ATM) has been known for decades as the main kinase mediating the DNA double-strand break response. Our recent findings suggest that its major role at the sites of breaks likely resides in its ability to modify both the local chromatin landscape and the global chromosome organization in order to promote repair accuracy.