Dysfunctional Reward Processing in Depression.
Dysfunctional Reward Processing in Depression.
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DOI：
10.1016/j.copsyc.2014.12.011
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发表时间：
2015-08-01
影响因子：
5.9
通讯作者：
Pizzagalli DA
中科院分区：
文献类型：
--
作者：
Admon R;Pizzagalli DA
快感缺失--快感减弱和/或对愉悦刺激的反应性降低--是抑郁症的核心特征，在治疗后经常持续存在。因此，人们一直致力于研究抑郁症中调节奖赏功能障碍的心理和生物过程。奖赏处理可以分解为包括动机、强化学习和享乐能力在内的子成分，根据临床前和神经成像证据，这些子成分涉及部分分离的大脑系统。与此一致的是，最近的发现表明，抑郁症的行为障碍和神经异常在不同的奖赏相关结构中存在差异。最终，提高对抑郁症中与奖赏相关的功能障碍的准确理解有望改善抑郁症的诊断和治疗努力。
Anhedonia - diminished pleasure and/or decreased reactivity to pleasurable stimuli - is a core feature of depression that frequently persists after treatment. As a result, extensive effort has been directed towards characterizing the psychological and biological processes that mediate dysfunctional reward processing in depression. Reward processing can be parsed into sub-components that include motivation, reinforcement learning, and hedonic capacity, which, according to preclinical and neuroimaging evidence, involve partially dissociable brain systems. In line with this, recent findings indicate that behavioral impairments and neural abnormalities in depression vary across distinct reward-related constructs. Ultimately, improved understanding of precise reward-related dysfunctions in depression promises to improve diagnostic and therapeutic efforts in depression.