Effect of antiviral treatment on evolution of liver steatosis in patients with chronic hepatitis C:: indirect evidence of a role of hepatitis C virus genotype 3 in steatosis
Effect of antiviral treatment on evolution of liver steatosis in patients with chronic hepatitis C:: indirect evidence of a role of hepatitis C virus genotype 3 in steatosis
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DOI：
10.1136/gut.2002.009936
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发表时间：
2004-03-01
期刊：
影响因子：
24.5
通讯作者：
Dhumeaux, D
中科院分区：
文献类型：
--
作者：
Castéra, L;Hézode, C;Dhumeaux, D
背景和目的：最近的研究表明，慢性丙型肝炎中的肝脏脂肪变性可能是丙型肝炎病毒（HCV）直接细胞病变效应的表现，特别是在感染基因型3的患者中。为了研究这一假设，我们研究了慢性丙型肝炎患者抗病毒治疗后脂肪变性和HCV清除之间的关系以及配对肝活检。方法：总共151名患者（37名HCV基因型3；114名HCV基因型3）非 3 基因型）根据以下标准进行选择：初始活检时存在脂肪变性；第一次活检前未接受抗病毒治疗；两次活检之间接受的抗病毒治疗；体重指数 (BMI)
Background and aim: Recent studies suggest that liver steatosis in chronic hepatitis C may be the expression of a direct cytopathic effect of hepatitis C virus (HCV), particularly in patients infected with genotype 3. To investigate this hypothesis, we studied the relationship between steatosis evolution and HCV clearance after antiviral treatment in patients with chronic hepatitis C and paired liver biopsies.Methods: A total of 151 patients (37 with HCV genotype 3; 114 with HCV non-3 genotypes) were selected according to the following criteria: presence of steatosis at initial biopsy; no antiviral treatment prior to the first biopsy; antiviral treatment received between the two biopsies; body mass index (BMI)