CALCIUM SOURCE FOR EXCITATION-CONTRACTION COUPLING IN MYOCARDIUM OF NONHIBERNATING AND HIBERNATING CHIPMUNKS
CALCIUM SOURCE FOR EXCITATION-CONTRACTION COUPLING IN MYOCARDIUM OF NONHIBERNATING AND HIBERNATING CHIPMUNKS
复制标题
DOI：
10.1126/science.6740332
复制
发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
SHIBATA, S
中科院分区：
文献类型：
--
作者：
KONDO, N;SHIBATA, S
冬眠花栗鼠心肌动作电位的平台期早期波幅和慢动作电位波幅明显低于非冬眠花栗鼠。频率依赖性收缩在冬眠动物中减少，但在非冬眠动物中增加。咖啡因对冬眠动物有负性变力作用，但对非冬眠动物有正性变力作用。与非冬眠动物相比，兰诺定对冬眠动物的抑制作用更强。在冬眠过程中，心肌兴奋-收缩偶联的钙离子源各自的作用可能发生变化。
The amplitude of the early plateau phase of the action potential and the slow action potential of cardiac muscle were much lower in hibernating chipmunks than in nonhibernating chipmunks. The frequency-dependent contraction was decreased in hibernating animals but increased in nonhibernating animals. Caffeine caused a negative inotropic effect in hibernating animals but a positive inotropic effect in nonhibernating animals. Ryanodine caused greater inhibition in hibernating animals than in nonhibernating animals. The respective roles of the sources of Ca for cardiac excitation-contraction coupling may change during hibernation.