Human Herpesvirus 8-Negative and Epstein-Barr Virus-Positive Effusion-Based Lymphoma in a Patient with Human Immunodeficiency Virus.
Human Herpesvirus 8-Negative and Epstein-Barr Virus-Positive Effusion-Based Lymphoma in a Patient with Human Immunodeficiency Virus.
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DOI：
10.4132/jptm.2015.06.03
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发表时间：
2015-09
影响因子：
2.4
通讯作者：
Kim YS
中科院分区：
文献类型：
--
作者：
Choi JW;Kim Y;Lee JH;Kim YS
一名39岁男性感染人类免疫缺陷病毒（HIV），因突发胸痛入院。胸部X光检查显示右肺气胸。计算机断层扫描显示右肺中叶有一个 5.8 厘米大小的肺气肿大泡。组织学上，楔形切除的肺在耶氏肺孢子虫肺炎的大疱腔内显示出中等至大的非典型细胞，没有固体肿块形成。这些非典型细胞被证实为大 B 细胞淋巴瘤、EB 病毒阳性和人类疱疹病毒 8 阴性。因此，该病例不被诊断为原发性渗出性淋巴瘤，而是HIV感染者肺气肿腔内发生的渗出性淋巴瘤。这种类型的基于渗出的淋巴瘤从未有过报道，虽然罕见，但在临床诊断这种淋巴瘤时应予以注意。
A 39-year-old man infected with human immunodeficiency virus (HIV) was admitted to our hospital because of sudden onset of chest pain. Chest radiography revealed pneumothorax of the right lung. Computed tomographic scans disclosed a 5.8-cm-sized emphysematous bulla in the right middle lobe of the lung. Histologically, the wedge-resected lung showed medium to large atypical cells within the bullous cavity of the Pneumocystis jirovecii pneumonia, without solid mass formation. These atypical cells were confirmed to be large B-cell lymphoma, Epstein-Barr virus–positive and human herpesvirus 8–negative. Therefore, this case was not diagnosed as primary effusion lymphoma, but effusion-based lymphoma arising in an emphysematous cavity of an HIV-infected patient. This type of effusion-based lymphoma has never been reported, and, although rare, it should be noted in order to clinically diagnose this lymphoma.