Nesfatin-1 and other hormone alterations in polycystic ovary syndrome
Nesfatin-1 and other hormone alterations in polycystic ovary syndrome
复制标题
DOI：
10.1007/s12020-012-9638-7
复制
发表时间：
2012-12-01
期刊：
影响因子：
3.7
通讯作者：
Gungor, Sami
中科院分区：
文献类型：
--
作者：
Deniz, Rulin;Gurates, Bilgin;Gungor, Sami
多囊卵巢综合征（PCOS）通常以肥胖、胰岛素抵抗（IR）、高雄激素血症和多毛症为特征。Nesfatin-1是最近发现的一种激素，作用于能量平衡、葡萄糖代谢、肥胖，可能还有性腺功能。本研究旨在评估多囊卵巢综合征（PCOS）患者（n = 30）和年龄和体重指数（BMI）匹配的对照组（n = 30）中nesfat -1的循环水平。PCOS患者的nesfatin-1水平（0.88 +/- A 0.36 ng/mL）明显低于健康对照组（2.22 +/- A 1.14 ng/mL）。PCOS患者的促性腺激素和雄激素血浆浓度、Ferriman-Gallwey评分、血糖水平和HOMA-IR指数（HOMA-IR）动态平衡模型也高于健康女性。PCOS患者的相关测试发现nesfatin-1水平与BMI、空腹血糖、胰岛素水平和HOMA-IR指数呈负相关。巢脂素-1浓度的降低可能在PCOS的发生发展中起重要作用。
Polycystic ovary syndrome (PCOS) is commonly characterised by obesity, insulin resistance (IR), hyperandrogenemia and hirsutism. Nesfatin-1 a recently discovered hormone, acts upon energy balance, glucose metabolism, obesity and probably gonadal functions. This study was to evaluate the circulating levels of nesfatin-1 in patients with PCOS (n = 30) and in age and body mass index (BMI)-matched controls (n = 30). PCOS patients had significantly lower levels of nesfatin-1 (0.88 +/- A 0.36 ng/mL) than healthy controls (2.22 +/- A 1.14 ng/mL). PCOS patients also had higher gonadotropin and androgen plasma concentrations, Ferriman-Gallwey scores, blood glucose levels and a homeostasis model of assessment-IR index (HOMA-IR) index than in healthy women. Correlation tests in PCOS subjects detected a negative correlation between nesfatin-1 levels and BMI, fasting blood glucose, insulin levels and a HOMA-IR index. Lower nesfatin-1 concentration may plays a very important role in the development of PCOS.