Distributions of heavy metals in maternal and cord blood and the association with infant birth weight in China.
Distributions of heavy metals in maternal and cord blood and the association with infant birth weight in China.
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发表时间：
2015
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通讯作者：
Xiaobin Hu;T. Zheng;Yibin Cheng;T. Holford;Shao-bin Lin;B. Leaderer;J. Qiu;B. Bassig;K. Shi;Yawei Zhang;J. Niu;Yong Zhu;Yonghong Li;Huan Guo;Qiong Chen;Jianqing Zhang;Shunqing Xu;Yinlong Jin
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作者：
Xiaobin Hu;T. Zheng;Yibin Cheng;T. Holford;Shao-bin Lin;B. Leaderer;J. Qiu;B. Bassig;K. Shi;Yawei Zhang;J. Niu;Yong Zhu;Yonghong Li;Huan Guo;Qiong Chen;Jianqing Zhang;Shunqing Xu;Yinlong Jin
目的测定中国孕妇及其新生儿血清重金属水平，探讨其与新生儿出生体重的关系。研究设计采用电感耦合等离子体质谱方法测定了81对母婴血清中铅、铊、镉、硒、砷、镍、钒、钴、汞的含量。使用多元线性回归分析来评估这些重金属与婴儿出生体重的关系。结果母血和脐血中Se、Pb、As和Cd的检出率最高(98.8%)，其次是Tl，分别占母血和脐血标本的79.0%和71.6%。在所有检测到的有毒金属中，母亲和脐带血样本中铅的浓度最高，分别为23.1 ng/g和22.0 ng/g。没有观察到任何重金属与出生体重之间的显著关联。然而，母血和脐带血中的TL与出生体重显著负相关。结论中国妇女及其新生儿的硒摄入量较低，而铅在所有检测到的有毒金属中母血和脐带血中的含量最高。TL是该人群中唯一的污染源，在这项初步研究中，TL水平对降低婴儿出生体重的影响最大。需要进一步的研究，纳入更大的样本量，以调查产前接触重金属--特别是Tl和铅--对中国婴儿出生结局的影响。
OBJECTIVE To measure serum levels of heavy metals in Chinese pregnant women and their newborns, and to evaluate the association of these metals with infant birth weight. STUDY DESIGN We measured serum concentrations of lead (Pb), thallium (Tl), cadmium (Cd), selenium (Se), arsenic (As), nickle (Ni), vanadium (V), cobalt (Co), and mercury (Hg) in 81 mother-infant pairs using an inductively coupled plasma mass spectrometry method. Multiple linear regression analyses were used to evaluate the associations of these heavy metals with infant birth weight. RESULTS Se, Pb, As, and Cd showed the highest detection rates (98.8%) in both the maternal and cord blood, followed by Tl, which was detected in 79.0% and 71.6% of the maternal and cord blood samples, respectively. Pb had the highest concentrations in both the maternal and cord blood samples of all toxic metals detected, with concentrations of 23.1 ng/g and 22.0 ng/g, respectively. No significant associations were observed between any heavy metals and birth weight. However, Tl in the maternal and cord blood was most notably inversely associated with birth weight. CONCLUSION Se intake was low in Chinese women and their newborns, whereas Pb had the highest concentrations in both the maternal and cord blood samples of all toxic metals detected. Tl was a unique pollution source in this population, and Tl levels were shown to have the largest effect on decreasing infant birth weight in this pilot study. Further research incorporating larger sample sizes is needed to investigate the effects of prenatal exposure to heavy metals--especially Tl and Pb--on birth outcome in Chinese infants.