Project TENDR: Targeting Environmental Neuro-Developmental Risks The TENDR Consensus Statement.
Project TENDR: Targeting Environmental Neuro-Developmental Risks The TENDR Consensus Statement.
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DOI：
10.1289/ehp358
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发表时间：
2016-07-01
影响因子：
10.4
通讯作者：
National Medical Association
中科院分区：
文献类型：
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作者：
Bennett D;Bellinger DC;Birnbaum LS;Bradman A;Chen A;Cory-Slechta DA;Engel SM;Fallin MD;Halladay A;Hauser R;Hertz-Picciotto I;Kwiatkowski CF;Lanphear BP;Marquez E;Marty M;McPartland J;Newschaffer CJ;Payne-Sturges D;Patisaul HB;Perera FP;Ritz B;Sass J;Schantz SL;Webster TF;Whyatt RM;Woodruff TJ;Zoeller RT;Anderko L;Campbell C;Conry JA;DeNicola N;Gould RM;Hirtz D;Huffling K;Landrigan PJ;Lavin A;Miller M;Mitchell MA;Rubin L;Schettler T;Tran HL;Acosta A;Brody C;Miller E;Miller P;Swanson M;Witherspoon NO;American College of Obstetricians and Gynecologists (ACOG);Child Neurology Society;Endocrine Society;International Neurotoxicology Association;International Society for Children’s Health and the Environment;International Society for Environmental Epidemiology;National Council of Asian Pacific Islander Physicians;National Hispanic Medical Association;National Medical Association
总结：今天的美国儿童患上影响大脑和神经系统的神经发育障碍的风险高得令人无法接受，包括自闭症、注意力缺陷多动障碍、智力残疾和其他学习和行为障碍。这些都是复杂的疾病，有多种原因-遗传，社会和环境。有毒化学品对这些疾病的影响是可以预防的。方法：领先的科学和医学专家，沿着儿童健康倡导者，在2015年在TENDR项目的主持下聚集在一起：针对环境神经发育风险，发出行动呼吁，以减少对干扰胎儿和儿童大脑发育的化学物质的广泛暴露。根据现有的科学证据，TENDR的作者已经确定了增加儿童神经发育障碍风险的有毒化学物质和污染物的主要例子。其中包括广泛用于消费品并已在环境中广泛使用的化学品。有些是儿童和孕妇经常接触的化学物质，在美国疾病控制和预防中心进行的全国调查中，几乎所有美国人的体内都检测到了这些化学物质。工业和消费品中的绝大多数化学品几乎没有经过发育神经毒性或其他健康影响的测试。结论：基于这些发现，我们断言，美国目前评估科学证据和对环境化学品做出基于健康的决定的系统从根本上被打破了。为了帮助降低我们儿童神经发育障碍的高患病率，我们必须消除或显著减少对导致这些疾病的化学物质的暴露。我们必须采用一个新的框架来评估有可能破坏大脑发育的化学品，并防止使用可能构成风险的化学品。该共识声明为制定监测、评估和减少神经毒性化学品暴露的建议奠定了基础。如果我们要保护健康的大脑发育，使今世后代能够充分发挥其潜力，就迫切需要采取这些措施。
Summary: Children in America today are at an unacceptably high risk of developing neurodevelopmental disorders that affect the brain and nervous system including autism, attention deficit hyperactivity disorder, intellectual disabilities, and other learning and behavioral disabilities. These are complex disorders with multiple causes—genetic, social, and environmental. The contribution of toxic chemicals to these disorders can be prevented. Approach: Leading scientific and medical experts, along with children’s health advocates, came together in 2015 under the auspices of Project TENDR: Targeting Environmental Neuro-Developmental Risks to issue a call to action to reduce widespread exposures to chemicals that interfere with fetal and children’s brain development. Based on the available scientific evidence, the TENDR authors have identified prime examples of toxic chemicals and pollutants that increase children’s risks for neurodevelopmental disorders. These include chemicals that are used extensively in consumer products and that have become widespread in the environment. Some are chemicals to which children and pregnant women are regularly exposed, and they are detected in the bodies of virtually all Americans in national surveys conducted by the U.S. Centers for Disease Control and Prevention. The vast majority of chemicals in industrial and consumer products undergo almost no testing for developmental neurotoxicity or other health effects. Conclusion: Based on these findings, we assert that the current system in the United States for evaluating scientific evidence and making health-based decisions about environmental chemicals is fundamentally broken. To help reduce the unacceptably high prevalence of neurodevelopmental disorders in our children, we must eliminate or significantly reduce exposures to chemicals that contribute to these conditions. We must adopt a new framework for assessing chemicals that have the potential to disrupt brain development and prevent the use of those that may pose a risk. This consensus statement lays the foundation for developing recommendations to monitor, assess, and reduce exposures to neurotoxic chemicals. These measures are urgently needed if we are to protect healthy brain development so that current and future generations can reach their fullest potential.