Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia
Altered resting-state functional connectivity and anatomical connectivity of hippocampus in schizophrenia
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DOI：
10.1016/j.schres.2007.11.039
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发表时间：
2008-03
影响因子：
4.5
通讯作者：
Yuan Zhou;N. Shu;Yong Liu;Ming Song;Yihui Hao;Haihong Liu;Chunshui Yu;Zhening Liu;T. Jiang-T.
中科院分区：
文献类型：
--
作者：
Yuan Zhou;N. Shu;Yong Liu;Ming Song;Yihui Hao;Haihong Liu;Chunshui Yu;Zhening Liu;T. Jiang-T.
海马体参与了精神分裂症的病理生理过程。然而，在精神分裂症患者中，很少同时研究海马体和其他区域之间的功能和解剖联系。对17例偏执型精神分裂症患者和14例正常人进行静息功能磁共振成像(FMRI)和弥散张量成像(DTI)检查。选择前海马区作为感兴趣区，分别分析双侧海马区静息状态下的功能连接性。穹隆体行弥散张量束成像重建，并用分数各向异性(FA)评价穹隆体束的完整性。在精神分裂症患者中，双侧海马区与一些已被报道参与情景记忆的区域的功能连接性降低，如后扣带回、纹外皮质、内侧前额叶皮质和海马旁回。我们推测，这些连接的减少可能反映了精神分裂症患者与前海马体相关的神经网络内的连接中断。同时患者穹隆体区平均FA明显降低，提示精神分裂症患者海马区解剖连接性受损。精神分裂症患者海马区与其他区域之间的功能缺失和解剖连接受损同时存在，提示其功能-解剖关系有待进一步研究。
Hippocampus has been implicated in participating in the pathophysiology of schizophrenia. However, the functional and anatomical connectivities between hippocampus and other regions are rarely concurrently investigated in schizophrenia. In the present study, both functional magnetic resonance imaging (fMRI) during rest and diffusion tensor imaging (DTI) were performed on 17 patients with paranoid schizophrenia and 14 healthy subjects. Resting-state functional connectivities of the bilateral hippocampi were separately analyzed by selecting the anterior hippocampus as region of interest. The fornix body was reconstructed by diffusion tensor tractography, and the integrity of this tract was evaluated using fractional anisotropy (FA). In patients with schizophrenia, the bilateral hippocampi showed reduced functional connectivities to some regions which have been reported to be involved in episodic memory, such as posterior cingulate cortex, extrastriate cortex, medial prefrontal cortex, and parahippocampus gyrus. We speculated that these reduced connectivity may reflect the disconnectivity within a neural network related to the anterior hippocampus in schizophrenia. Meanwhile the mean FA of the fornix body was significantly reduced in patients, indicating the damage in the hippocampal anatomical connectivity in schizophrenia. The concurrence of the functional disconnectivity and damaged anatomical connectivity between the hippocampus and other regions in schizophrenia suggest that the functional–anatomical relationship need to be further investigated.