GLYCOSAMINOGLYCANS PREVENT MORPHOLOGICAL RENAL ALTERATIONS AND ALBUMINURIA IN DIABETIC RATS
GLYCOSAMINOGLYCANS PREVENT MORPHOLOGICAL RENAL ALTERATIONS AND ALBUMINURIA IN DIABETIC RATS
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DOI：
10.1038/ki.1992.288
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发表时间：
1992-08-01
影响因子：
19.6
通讯作者：
BAGGIO, B
中科院分区：
文献类型：
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作者：
GAMBARO, G;CAVAZZANA, AO;BAGGIO, B
糖胺聚糖代谢异常参与糖尿病肾病的解剖功能紊乱的发生，并决定了肾小球基底膜阴离子电荷的丢失，导致蛋白尿。 糖胺聚糖给药显示增加血管壁的负电位，抑制肾小球系膜细胞增殖，这是糖尿病肾病的解剖学标志，并减缓肾次全切除大鼠（一种与糖尿病肾病共享一些发病关键事件的模型）向尿毒症的进展。 基于这些考虑，我们验证了外源性糖胺聚糖对链脲佐菌素糖尿病大鼠肾脏受累的影响。 两种糖胺聚糖（低分子量肝素和硫酸皮肤素）的长期给药可防止肾小球基底膜增厚、肾小球阴离子电荷减少以及蛋白尿的发生，而不影响肾小球滤过率和疾病的代谢控制。 我们的数据表明，长期给予糖胺聚糖对糖尿病大鼠肾脏形态和功能异常有良好的影响。
Abnormal glycosaminoglycan metabolism is involved in the onset of anatomo-functional derangements in diabetic nephropathy, and determines the loss of glomerular basement membrane anionic charges leading to albuminuria. Glycosaminoglycan administration was shown to increase the negative electrical potential of the vessel wall, inhibit mesangial cell proliferation, which is an anatomical hallmark of diabetic nephropathy, and slow down the progression to uremia in subtotally nephrectomized rats, a model that shares some pathogenetic key events with diabetic nephropathy. Based on these considerations, we verified the effect of exogenous glycosaminoglycans on renal involvement in streptozotocin diabetic rats. Long-term administration of two glycosaminoglycans (low-molecular weight heparin and dermatan sulphate) prevented glomerular basement membrane thickening, glomerular anionic charge reduction, as well as the onset of albuminuria without affecting glomerular filtration rate and metabolic control of the disease. Our data demonstrate that the long-term administration of glycosaminoglycans has a favorable effect on morphological and functional renal abnormalities in diabetic rats.