Modulation of antitumor responses by dendritic cells.
Modulation of antitumor responses by dendritic cells.
复制标题
树突状细胞抗肿瘤反应的调节。
DOI：
10.1007/s00281-004-0175-1
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Jackson,Andrew
中科院分区：
文献类型：
--
作者：
Vieweg,Johannes;Jackson,Andrew
The discovery that dendritic cells (DC) play a key role in regulating antitumor immunity has prompted considerable efforts in developing DC-based cancer vaccines for use in clinical oncology. Early translational trials using antigen-loaded DC have established clear evidence of vaccine safety, and demonstrated bioactivity by stimulating immunological and even clinical responses in selected subjects. Despite these encouraging results, the vaccine-induced immune responses achieved to date are not yet sufficient to attain a robust and durable therapeutic effect in the cancer patient. Therefore, further improvements are required to enhance vaccine potency and optimize the potential for clinical success. This article presents a set of emerging concepts that, together, form a framework for a multi-pronged approach that will further enhance the efficacy of DC-based vaccination by either directly improving DC-mediated T cell activation or by inhibiting mechanisms that suppress the induction of an effective antitumor response. The clinical translation of these concepts will result in new opportunities to successfully modulate immune responses in clinical settings.
