An attempt to estimate the global burden of disease due to fluoride in drinking water
An attempt to estimate the global burden of disease due to fluoride in drinking water
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DOI：
10.2166/wh.2006.0036
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发表时间：
2006-12-01
影响因子：
2.3
通讯作者：
Bartram, Jamie
中科院分区：
文献类型：
--
作者：
Fewtrell, Lorna;Smith, Stuart;Bartram, Jamie
进行了一项研究，以检验估计饮用水中氟化物造成的全球疾病负担的可行性。氟骨症是一种严重的、使人衰弱的疾病，除中国的一个地区外，其绝大多数是由于饮用水中氟化物含量升高造成的。通过将氟牙和氟骨症的暴露-反应曲线（来自已发表的数据）与模型得出的预测饮用水氟化物浓度和暴露人口百分比估计值相结合，估算了饮用水中氟化物造成的全球疾病负担。几乎没有数据可用来验证输出，但考虑到目前所用数据的不确定性，无论是形成暴露-响应曲线还是氟化物浓度预测所产生的数据，人们认为估计不太可能成为途径，特别是，该工作已经确定了许多数据差距和有用的研究途径，特别是在确定暴露方面，这可能有助于未来对该问题的估计。
A study was conducted to examine the feasibility of estimating the global burden of disease due to fluoride in drinking water. Skeletal fluorosis is a serious and debilitating disease which, with the exception of one area in China is overwhelmingly due to the presence of elevated fluoride levels in drinking water.The global burden of disease due to fluoride in drinking water was estimated by combining exposure-response curves for dental and skeletal fluorosis (derived from published data) with model-derived predicted drinking water fluoride concentrations and an estimate of the percentage population exposed. There are few data with which to validate the output but given the current uncertainties in the data used, both to form the exposure-response curves and those resulting from the prediction of fluoride concentrations, it is felt that the estimate is unlikely to be avenues, especially, the exercise has identified a number of data gaps and useful research avenues, especially in relation to determining exposure, which could contribute to future estimates of this problem.