Long-term impact of prognostic nutritional index in cervical esophageal squamous cell carcinoma patients undergoing definitive radiotherapy
Long-term impact of prognostic nutritional index in cervical esophageal squamous cell carcinoma patients undergoing definitive radiotherapy
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DOI：
10.21037/atm.2019.03.60
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发表时间：
2019-04-01
影响因子：
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通讯作者：
Li, Jiancheng
中科院分区：
文献类型：
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作者：
Dai, Yaqing;Fu, Xiaobin;Li, Jiancheng
背景资料：预后营养指数（PNI）已被发现在几种癌症中具有预后价值，我们的目的是确定其对接受放化疗（CRT）治疗的颈段食管鳞状细胞癌（CESCC）患者的长期预后的预测价值。对福建医科大学附属肿瘤医院6月1日开始接受放疗加化疗或不加化疗的106例CESCC患者的资料进行分析，2000年至2015年12月31日进行回顾性分析。根据治疗前进行的血清测量，PNI计算为白蛋白（g/L）+5 ×总淋巴细胞计数。采用Kaplan-Meier法和考克斯比例回归模型分析PNI与总生存期（OS）的关系。PNI的最佳截止值计算为48.15，并将患者分为低PNI组（= 48.15）。单因素分析显示男性患者生存率低（P=0.004），肿瘤长度≥ 5.0 cm（P=0.043），放射治疗技术（P=0.016），同步化疗（P=0.012），淋巴细胞-单核细胞比率（LMR）（P=0.007）、中性粒细胞-淋巴细胞比值（NLR）（P=0.007）、肺癌炎症指数（ALI）（P=0.008）、颈段食管癌炎症指数（CEI）（P=0.043）、PNI（P
Background: The prognostic nutritional index (PNI) has been found to have prognostic value in several cancers, and we aimed to determine its predictive value for the long-term prognosis of cervical esophageal squamous cell carcinoma (CESCC) patients treated with chemoradiotherapy (CRT).Methods: The data for 106 CESCC patients who received radiotherapy with or without chemotherapy at the Cancer Hospital of Fujian Medical University from June 1, 2000 to December 31, 2015 were retrospectively analyzed. According to serum measurements taken before therapy, the PNI was calculated as albumin (g/L) + 5 x total lymphocyte count. The association between PNI and overall survival (OS) was determined by the Kaplan-Meier method and Cox proportional regression model analysis.Results: The median follow-up time was 19 months. The optimal cutoff value for PNI was calculated to be 48.15, and patients were divided into a low PNI group (= 48.15). Univariate analysis showed that a low survival rate was significantly associated with male gender (P=0.004), tumor length >= 5.0 cm (P=0.043), radiotherapy technique (P=0.016), synchronous chemotherapy (P=0.012), lymphocyte-monocyte ratio (LMR) (P=0.007), neutrophil-lymphocyte ratio (NLR) (P=0.007), lung cancer inflammation index (ALI) (P=0.008), cervical esophageal carcinoma inflammation index (CEI) (P=0.043), and PNI (P